U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Trim36 tripartite motif-containing 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291597, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim36provided by RGD
    Official Full Name
    tripartite motif-containing 36provided by RGD
    Primary source
    RGD:1308714
    See related
    EnsemblRapid:ENSRNOG00000016612 AllianceGenome:RGD:1308714
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-tubulin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including acrosome reaction; regulation of microtubule cytoskeleton organization; and spindle organization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in acrosomal vesicle. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human TRIM36 (tripartite motif containing 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 35.7), Brain (RPKM 25.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trim36 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (41047657..41099497, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (38859604..38912859, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (40081028..40134673, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27a, pseudogene 13 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L31 like 16 Neighboring gene uncharacterized LOC120098337 Neighboring gene protein geranylgeranyltransferase type I subunit beta Neighboring gene uncharacterized LOC134483014 Neighboring gene coiled-coil domain containing 112

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in acrosome reaction  
    acts_upstream_of_or_within acrosome reaction  
    involved_in mitotic cytokinesis  
    involved_in regulation of cell cycle  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in spindle organization  
    involved_in spindle organization  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle  
    located_in acrosomal vesicle  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM36
    Names
    tripartite motif protein 36
    NP_001099617.1
    XP_006254748.1
    XP_038952628.1
    XP_038952629.1
    XP_038952630.1
    XP_038952631.1
    XP_063133283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106147.1NP_001099617.1  E3 ubiquitin-protein ligase TRIM36

      See identical proteins and their annotated locations for NP_001099617.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473971
      UniProtKB/TrEMBL
      A0A8I5ZKQ5, A6IWV0, F1LY63
      Related
      ENSRNOP00000022294.6, ENSRNOT00000022294.9
      Conserved Domains (5) summary
      smart00060
      Location:431494
      FN3; Fibronectin type 3 domain
      cd00021
      Location:211249
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:3361
      zf-RING_UBOX; RING-type zinc-finger
      cd12894
      Location:516719
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:256380
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      41047657..41099497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254686.5XP_006254748.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW11, A0A8I5ZKQ5
      Related
      ENSRNOP00000110746.1, ENSRNOT00000155574.1
      Conserved Domains (5) summary
      smart00060
      Location:419482
      FN3; Fibronectin type 3 domain
      cd00021
      Location:199237
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:2149
      zf-RING_UBOX; RING-type zinc-finger
      cd12894
      Location:504707
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:244368
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. XM_039096700.2XP_038952628.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

      Conserved Domains (7) summary
      smart00502
      Location:244368
      BBC; B-Box C-terminal domain
      smart00060
      Location:419482
      FN3; Fibronectin type 3 domain
      cd16756
      Location:16113
      RING-HC_TRIM36; RING finger, HC subclass, found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      cd19778
      Location:198242
      Bbox2_TRIM36_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      cd19848
      Location:139193
      Bbox1_TRIM36_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      pfam18568
      Location:347395
      COS; TRIM C-terminal subgroup One Signature domain
      cl02614
      Location:504560
      SPRY; SPRY domain
    3. XM_063277213.1XP_063133283.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKQ5
    4. XM_039096703.2XP_038952631.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

      Conserved Domains (4) summary
      smart00502
      Location:296
      BBC; B-Box C-terminal domain
      smart00060
      Location:147210
      FN3; Fibronectin type 3 domain
      cd12894
      Location:232435
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      pfam18568
      Location:75123
      COS; TRIM C-terminal subgroup One Signature domain
    5. XM_039096702.2XP_038952630.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

      Conserved Domains (4) summary
      smart00502
      Location:296
      BBC; B-Box C-terminal domain
      smart00060
      Location:147210
      FN3; Fibronectin type 3 domain
      cd12894
      Location:232435
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      pfam18568
      Location:75123
      COS; TRIM C-terminal subgroup One Signature domain
    6. XM_039096701.2XP_038952629.1  E3 ubiquitin-protein ligase TRIM36 isoform X4

      Conserved Domains (6) summary
      smart00502
      Location:244368
      BBC; B-Box C-terminal domain
      smart00060
      Location:419482
      FN3; Fibronectin type 3 domain
      cd16756
      Location:16113
      RING-HC_TRIM36; RING finger, HC subclass, found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      cd19778
      Location:198242
      Bbox2_TRIM36_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      cd19848
      Location:139193
      Bbox1_TRIM36_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      pfam18568
      Location:347395
      COS; TRIM C-terminal subgroup One Signature domain
    External link. Please review our privacy policy.