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    Kcnma1 potassium calcium-activated channel subfamily M alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83731, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnma1provided by RGD
    Official Full Name
    potassium calcium-activated channel subfamily M alpha 1provided by RGD
    Primary source
    RGD:620715
    See related
    EnsemblRapid:ENSRNOG00000005985 AllianceGenome:RGD:620715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slo; BKCa; cbv1; slo1; Kcnma; maxiK; KCa1.1; KCNMA1b; KCNMA1c; slo-alpha; BKCA alpha; k(VCA)alpha
    Summary
    Enables identical protein binding activity and monoatomic ion channel activity. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Located in several cellular components, including external side of plasma membrane; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; and paroxysmal nonkinesigenic dyskinesia 3. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 166.7), Adrenal (RPKM 61.8) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnma1 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (351065..1057117)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (302480..1007675)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (344204..1048849)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693799 Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene U6 spliceosomal RNA Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA threonine (anticodon AGU) 13

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-activated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-activated potassium channel activity TAS
    Traceable Author Statement
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables large conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables large conductance calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables large conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables large conductance calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel diameter maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within columnar/cuboidal epithelial cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eye blink reflex ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotor rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell volume IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of cell volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of small intestine smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of aldosterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within relaxation of vascular associated smooth muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in relaxation of vascular associated smooth muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to carbon monoxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to carbon monoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within saliva secretion ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle contraction involved in micturition IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within smooth muscle contraction involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle contraction involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium-activated potassium channel subunit alpha-1
    Names
    BK channel
    calcium-activated potassium channel alpha subunit
    calcium-activated potassium channel, subfamily M subunit alpha-1
    maxi K channel
    potassium channel, calcium activated large conductance subfamily M alpha, member 1
    potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    slo homolog
    slowpoke homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393699.1NP_001380628.1  calcium-activated potassium channel subunit alpha-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKU7
      Related
      ENSRNOP00000082424.2, ENSRNOT00000109865.2
      Conserved Domains (2) summary
      PLN03192
      Location:217393
      PLN03192; Voltage-dependent potassium channel; Provisional
      PRK10537
      Location:343415
      PRK10537; voltage-gated potassium channel protein
    2. NM_001393700.1NP_001380629.1  calcium-activated potassium channel subunit alpha-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKU6, A6KKU7
      Related
      ENSRNOP00000071652.3, ENSRNOT00000091318.3
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:538633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:446523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001393701.1NP_001380630.1  calcium-activated potassium channel subunit alpha-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
      UniProtKB/TrEMBL
      A0A8I6ABY5
      Conserved Domains (2) summary
      PLN03192
      Location:217393
      PLN03192; Voltage-dependent potassium channel; Provisional
      PRK10537
      Location:343415
      PRK10537; voltage-gated potassium channel protein
    4. NM_031828.2NP_114016.2  calcium-activated potassium channel subunit alpha-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
      UniProtKB/TrEMBL
      A0A8I6A598
      Related
      ENSRNOP00000086150.2, ENSRNOT00000105174.2
      Conserved Domains (2) summary
      PLN03192
      Location:217393
      PLN03192; Voltage-dependent potassium channel; Provisional
      PRK10537
      Location:343415
      PRK10537; voltage-gated potassium channel protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      351065..1057117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274728.1XP_063130798.1  calcium-activated potassium channel subunit alpha-1 isoform X30

    2. XM_063274726.1XP_063130796.1  calcium-activated potassium channel subunit alpha-1 isoform X28

    3. XM_063274727.1XP_063130797.1  calcium-activated potassium channel subunit alpha-1 isoform X29

    4. XM_063274699.1XP_063130769.1  calcium-activated potassium channel subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A6KKU7
    5. XM_063274700.1XP_063130770.1  calcium-activated potassium channel subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A6KKU7
    6. XM_063274706.1XP_063130776.1  calcium-activated potassium channel subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A6KKU7
    7. XM_063274707.1XP_063130777.1  calcium-activated potassium channel subunit alpha-1 isoform X9

      UniProtKB/TrEMBL
      A6KKU7
    8. XM_063274702.1XP_063130772.1  calcium-activated potassium channel subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K8Q9
    9. XM_063274703.1XP_063130773.1  calcium-activated potassium channel subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8Q9
    10. XM_063274704.1XP_063130774.1  calcium-activated potassium channel subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      A6KKU7
    11. XM_063274705.1XP_063130775.1  calcium-activated potassium channel subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A6KKU7
    12. XM_063274709.1XP_063130779.1  calcium-activated potassium channel subunit alpha-1 isoform X11

      UniProtKB/TrEMBL
      A6KKU7
    13. XM_063274710.1XP_063130780.1  calcium-activated potassium channel subunit alpha-1 isoform X12

      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
    14. XM_063274701.1XP_063130771.1  calcium-activated potassium channel subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A6KKU7
    15. XM_063274715.1XP_063130785.1  calcium-activated potassium channel subunit alpha-1 isoform X17

      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
      UniProtKB/TrEMBL
      F1LNC7
    16. XM_063274708.1XP_063130778.1  calcium-activated potassium channel subunit alpha-1 isoform X10

      UniProtKB/TrEMBL
      A6KKU7
    17. XM_063274714.1XP_063130784.1  calcium-activated potassium channel subunit alpha-1 isoform X16

      UniProtKB/TrEMBL
      A6KKU7
    18. XM_063274711.1XP_063130781.1  calcium-activated potassium channel subunit alpha-1 isoform X13

      UniProtKB/TrEMBL
      A6KKU7
      Related
      ENSRNOP00000058962.5, ENSRNOT00000065542.6
    19. XM_063274729.1XP_063130799.1  calcium-activated potassium channel subunit alpha-1 isoform X31

      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
    20. XM_063274717.1XP_063130787.1  calcium-activated potassium channel subunit alpha-1 isoform X19

      UniProtKB/TrEMBL
      A6KKU7
    21. XM_063274720.1XP_063130790.1  calcium-activated potassium channel subunit alpha-1 isoform X22

      UniProtKB/TrEMBL
      A0A8I5ZV96
    22. XM_063274716.1XP_063130786.1  calcium-activated potassium channel subunit alpha-1 isoform X18

      UniProtKB/TrEMBL
      A6KKU7, A6KKU8
    23. XM_063274723.1XP_063130793.1  calcium-activated potassium channel subunit alpha-1 isoform X25

      UniProtKB/TrEMBL
      A6KKU7
    24. XM_063274712.1XP_063130782.1  calcium-activated potassium channel subunit alpha-1 isoform X14

      UniProtKB/TrEMBL
      A6KKU7
    25. XM_063274713.1XP_063130783.1  calcium-activated potassium channel subunit alpha-1 isoform X15

      UniProtKB/TrEMBL
      A6KKU7
    26. XM_063274722.1XP_063130792.1  calcium-activated potassium channel subunit alpha-1 isoform X24

      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
    27. XM_063274724.1XP_063130794.1  calcium-activated potassium channel subunit alpha-1 isoform X26

      UniProtKB/Swiss-Prot
      O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3
    28. XM_063274730.1XP_063130800.1  calcium-activated potassium channel subunit alpha-1 isoform X32

      UniProtKB/TrEMBL
      A0A8I5ZV96
      Related
      ENSRNOP00000096569.1, ENSRNOT00000109388.2
    29. XM_063274721.1XP_063130791.1  calcium-activated potassium channel subunit alpha-1 isoform X23

      UniProtKB/TrEMBL
      A0A0G2K8Q9, A6KKU5
      Related
      ENSRNOP00000061684.4, ENSRNOT00000066928.5
    30. XM_063274725.1XP_063130795.1  calcium-activated potassium channel subunit alpha-1 isoform X27

      UniProtKB/TrEMBL
      A6KKU7
    31. XM_063274718.1XP_063130788.1  calcium-activated potassium channel subunit alpha-1 isoform X20

      UniProtKB/TrEMBL
      A6KKU7
    32. XM_063274719.1XP_063130789.1  calcium-activated potassium channel subunit alpha-1 isoform X21

      UniProtKB/TrEMBL
      A6KKU7