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    Cct8 chaperonin containing TCP1 subunit 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288305, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cct8provided by RGD
    Official Full Name
    chaperonin containing TCP1 subunit 8provided by RGD
    Primary source
    RGD:1305452
    See related
    EnsemblRapid:ENSRNOG00000001592 AllianceGenome:RGD:1305452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in several cellular components, including cell body; cytoskeleton; and nucleoplasm. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 610.9), Heart (RPKM 567.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cct8 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (40196619..40208328, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (26710370..26722079, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (27130172..27141881, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene RWD domain containing 2B Neighboring gene ubiquitin specific peptidase 16 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L32, pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent protein folding chaperone  
    enables protein folding chaperone  
    enables unfolded protein binding  
    Component Evidence Code Pubs
    located_in cell body  
    located_in cell projection  
    located_in centrosome  
    part_of chaperonin-containing T-complex  
    part_of chaperonin-containing T-complex  
    located_in cytoplasm  
    located_in cytosol  
    located_in intermediate filament cytoskeleton  
    located_in intermediate filament cytoskeleton  
    located_in microtubule  
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of zona pellucida receptor complex  

    General protein information

    Preferred Names
    T-complex protein 1 subunit theta
    Names
    chaperonin containing Tcp1, subunit 8 (theta)
    chaperonin subunit 8 (theta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105897.2NP_001099367.2  T-complex protein 1 subunit theta

      See identical proteins and their annotated locations for NP_001099367.2

      Status: VALIDATED

      Source sequence(s)
      CO400743, CV076369, DY312304, DY319674, JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JL77, A6JL78, D4ACB8
      Related
      ENSRNOP00000002169.4, ENSRNOT00000002169.8
      Conserved Domains (2) summary
      TIGR02346
      Location:10539
      chap_CCT_theta; T-complex protein 1, theta subunit
      pfam00118
      Location:39528
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      40196619..40208328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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