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    Desi2 desumoylating isopeptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289277, updated on 9-Dec-2024

    Summary

    Official Symbol
    Desi2provided by RGD
    Official Full Name
    desumoylating isopeptidase 2provided by RGD
    Primary source
    RGD:1359392
    See related
    EnsemblRapid:ENSRNOG00000004524 AllianceGenome:RGD:1359392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DeSI-2; PNAS-4; Pppde1; CGI-146; Fam152a
    Summary
    Predicted to enable deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in macromolecule depalmitoylation and proteolysis. Predicted to be located in cytoplasm. Orthologous to human DESI2 (desumoylating isopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 58.3), Adrenal (RPKM 56.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Desi2 in Genome Data Viewer
    Location:
    13q25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (92493765..92543307)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (89961767..90011255)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (96111800..96156693)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 2 Neighboring gene catsper channel auxiliary subunit epsilon Neighboring gene uncharacterized LOC120096322 Neighboring gene ribosomal protein S16, pseudogene 3 Neighboring gene chromosome 13 C1orf202 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity  
    enables K48-linked deubiquitinase activity  
    enables K48-linked deubiquitinase activity  
    enables K63-linked deubiquitinase activity  
    enables K63-linked deubiquitinase activity  
    enables K63-linked deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables deubiquitinase activity  
    enables long-chain fatty acyl-CoA hydrolase activity  
    enables long-chain fatty acyl-CoA hydrolase activity  
    enables long-chain fatty acyl-CoA hydrolase activity  
    enables palmitoyl-(protein) hydrolase activity  
    enables peptidase activity  
    Process Evidence Code Pubs
    involved_in macromolecule depalmitoylation  
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    deubiquitinase DESI2
    Names
    PPPDE peptidase domain containing 1
    PPPDE peptidase domain-containing protein 1
    S-depalmitoylase DESI2
    family with sequence similarity 152, member A
    palmitoyl protein thioesterase DESI2
    NP_001013895.1
    XP_006250379.1
    XP_017454213.1
    XP_017454214.1
    XP_038946457.1
    XP_038946458.1
    XP_038946460.1
    XP_063128204.1
    XP_063128205.1
    XP_063128206.1
    XP_063128207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013873.1NP_001013895.1  deubiquitinase DESI2

      See identical proteins and their annotated locations for NP_001013895.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083584
      UniProtKB/Swiss-Prot
      Q5XIT6
      UniProtKB/TrEMBL
      A0A8I6GJD8
      Related
      ENSRNOP00000005967.5, ENSRNOT00000005967.9
      Conserved Domains (1) summary
      pfam05903
      Location:7149
      Peptidase_C97; PPPDE putative peptidase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      92493765..92543307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090530.2XP_038946458.1  deubiquitinase DESI2 isoform X4

      Conserved Domains (1) summary
      pfam05903
      Location:7112
      Peptidase_C97; PPPDE putative peptidase domain
    2. XM_039090532.2XP_038946460.1  deubiquitinase DESI2 isoform X6

      Conserved Domains (1) summary
      pfam05903
      Location:7118
      Peptidase_C97; PPPDE putative peptidase domain
    3. XM_017598724.3XP_017454213.1  deubiquitinase DESI2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF15, A0A8I6GJD8
      Related
      ENSRNOP00000103188.1, ENSRNOT00000130824.1
      Conserved Domains (1) summary
      pfam05903
      Location:16145
      Peptidase_C97; PPPDE putative peptidase domain
    4. XM_006250317.5XP_006250379.1  deubiquitinase DESI2 isoform X2

      See identical proteins and their annotated locations for XP_006250379.1

      UniProtKB/TrEMBL
      A0A8I6AD20, A0A8I6AER3
      Related
      ENSRNOP00000107831.1, ENSRNOT00000149433.1
      Conserved Domains (1) summary
      pfam05903
      Location:14143
      Peptidase_C97; PPPDE putative peptidase domain
    5. XM_017598725.3XP_017454214.1  deubiquitinase DESI2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF15, A0A8I6GJD8
      Conserved Domains (1) summary
      pfam05903
      Location:16145
      Peptidase_C97; PPPDE putative peptidase domain
    6. XM_039090529.2XP_038946457.1  deubiquitinase DESI2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJD8
      Related
      ENSRNOP00000091146.2, ENSRNOT00000098343.2
      Conserved Domains (1) summary
      pfam05903
      Location:10139
      Peptidase_C97; PPPDE putative peptidase domain
    7. XM_063272136.1XP_063128206.1  deubiquitinase DESI2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AD20, A0A8I6AER3
    8. XM_063272137.1XP_063128207.1  deubiquitinase DESI2 isoform X5

    9. XM_063272134.1XP_063128204.1  deubiquitinase DESI2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF15, A0A8I6GJD8
    10. XM_063272135.1XP_063128205.1  deubiquitinase DESI2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF15, A0A8I6GJD8
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