Ptgr1 prostaglandin reductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgr1provided by RGD
Official Full Name: prostaglandin reductase 1provided by RGD
Primary source: RGD:621195
See related: EnsemblRapid:ENSRNOG00000015072 AllianceGenome:RGD:621195
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dig1; Ltb4dh
Summary: Enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity and 2-alkenal reductase (NADPH) activity. Involved in several processes, including leukotriene B4 metabolic process; negative regulation of reactive oxygen species biosynthetic process; and response to antineoplastic agent. Located in cytosol and nucleus. Biomarker of hypertension. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 331.6), Liver (RPKM 251.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (78579060..78597671, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (73784000..73802624, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (76110746..76129361, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ptgr1 was overexpressed during the early phase in altered hepatocyte foci, and this high level of expression was maintained in persistent nodules until tumors developed. Ptgr1 expression was regulated by NRF2, which bound to an antioxidant response element at -653bp in the rat Ptgr1 gene.
Title: Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress.
The increased expression and activity of PTGR1 in liver carcinogenesis encourage further research aimed at understanding the metabolic role of PTGR1 in HCC and its potential application for human cancer diagnosis and treatment
Title: Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats.
These results situate PtGR-1 as a critical modulator of both the steady state levels and signaling activities of fatty acid nitroalkenes in vivo.
Title: Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.
These data showed unequivocally that Ltb4dh mediated net trans-addition of hydrogen to (R)-perillaldehyde but followed the opposite stereochemical course (net syn-addition) for (S)-perillaldehyde.
Title: Opposite stereochemical courses for enzyme-mediated alkene reductions of an enantiomeric substrate pair.

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General gene information

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Markers

D19S409 (e-PCR)
- UniSTS:54442

RH137513 (e-PCR)
- UniSTS:219601

BM386490 (e-PCR)
- UniSTS:261342

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 13-lipoxin reductase activity	ISO Inferred from Sequence Orthology more info
enables 13-lipoxin reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables 2-alkenal reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-alkenal reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 2-alkenal reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables leukotriene B4 12-hydroxy dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables leukotriene B4 12-hydroxy dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in alkene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene B4 metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene B4 metabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene B4 metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoxin A4 metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipoxin A4 metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to antineoplastic agent	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostaglandin reductase 1

Names: 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; DIG-1; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; dithiolethione-inducible gene 1 protein; dithiolethione-inducible gene-1; leukotriene B4 12-hydroxydehydrogenase

NP_620218.1

EC 1.3.1.48

EC 1.3.1.74

XP_017448631.1

EC 1.3.1.48

EC 1.3.1.74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.