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    Cdkl2 cyclin dependent kinase like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305242, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdkl2provided by RGD
    Official Full Name
    cyclin dependent kinase like 2provided by RGD
    Primary source
    RGD:1309625
    See related
    EnsemblRapid:ENSRNOG00000002506 AllianceGenome:RGD:1309625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 93.9), Testes (RPKM 42.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Cdkl2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16312154..16347524)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (16027381..16063257)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17530170..17565950)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 1 Neighboring gene uncharacterized LOC120096578 Neighboring gene small Cajal body-specific RNA 23 like 2 Neighboring gene Sec61 translocon subunit gamma, pseudogene 2 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene THAP domain containing 6 Neighboring gene ring finger and CHY zinc finger domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    cyclin-dependent kinase-like 2
    Names
    cyclin-dependent kinase-like 2 (CDC2-related kinase)
    NP_001012035.2
    XP_063129130.1
    XP_063129131.1
    XP_063129132.1
    XP_063129133.1
    XP_063129134.1
    XP_063129135.1
    XP_063129136.1
    XP_063129137.1
    XP_063129138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012035.2NP_001012035.2  cyclin-dependent kinase-like 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
      Related
      ENSRNOP00000049130.4, ENSRNOT00000050038.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      16312154..16347524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273060.1XP_063129130.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
      Related
      ENSRNOP00000073081.3, ENSRNOT00000079304.3
    2. XM_063273062.1XP_063129132.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    3. XM_063273066.1XP_063129136.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    4. XM_063273067.1XP_063129137.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    5. XM_063273061.1XP_063129131.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    6. XM_063273065.1XP_063129135.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    7. XM_063273063.1XP_063129133.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    8. XM_063273068.1XP_063129138.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
    9. XM_063273064.1XP_063129134.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
      Related
      ENSRNOP00000045371.4, ENSRNOT00000046771.6

    RNA

    1. XR_005492936.2 RNA Sequence

    2. XR_005492939.2 RNA Sequence

    3. XR_005492943.2 RNA Sequence

    4. XR_005492940.2 RNA Sequence

    5. XR_005492944.2 RNA Sequence

    6. XR_005492937.2 RNA Sequence

    7. XR_005492941.2 RNA Sequence

    8. XR_005492945.2 RNA Sequence

    9. XR_005492938.2 RNA Sequence

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