Qki QKI, KH domain containing RNA binding [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Qkiprovided by RGD
Official Full Name: QKI, KH domain containing RNA bindingprovided by RGD
Primary source: RGD:1584886
See related: EnsemblRapid:ENSRNOG00000048297 AllianceGenome:RGD:1584886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Qk
Summary: Predicted to enable RNA binding activity; internal N(7)-methylguanine-containing RNA reader activity; and transcription coactivator activity. Involved in several processes, including mRNA stabilization; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of oligodendrocyte differentiation. Predicted to be active in several cellular components, including cytoplasmic stress granule; cytosol; and synapse. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1051.2), Brain (RPKM 909.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (52935357..53047338)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (50387716..50501568)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (50983647..51050692)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes.
Title: The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes.
QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1-PPARgamma-PGC-1alpha axis.
Title: QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1-PPARγ-PGC-1α axis.
extracellular vesicles-mediated transfer of miR-208a/b can exaggerate H/R injury in cardiomyocytes by reducing QKI expression. This represents a previously unrecognized pathway of H/R injury in cardiomyocytes.
Title: Extracellular vesicles-mediated transfer of miR-208a/b exaggerate hypoxia/reoxygenation injury in cardiomyocytes by reducing QKI expression.
The overexpression of either QKI5 or QKI6 suppressed IR-induced apoptosis substantially.
Title: RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes.
the QKI-6 and QKI-7 RNA binding proteins are positive regulators of PNS myelination that play a key role in Schwann cell differentiation and myelination
Title: The QKI-6 and QKI-7 RNA binding proteins block proliferation and promote Schwann cell myelination.
QKI isoforms are necessary and sufficient for promoting OPC development, which must involve direct influence of QKI on differentiation/maturation of OPCs independent of cell cycle exit
Title: The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Qk (e-PCR), detects polymorphism
- UniSTS:464688

BF394556 (e-PCR)
- UniSTS:244791

BE111947 (e-PCR)
- UniSTS:245820

QKI (e-PCR)
- UniSTS:266175

Qk (e-PCR), detects polymorphism
- UniSTS:479216

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables internal N(7)-methylguanine-containing RNA reader activity	IEA Inferred from Electronic Annotation more info
enables internal N(7)-methylguanine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon ensheathment	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular mRNA localization	IEA Inferred from Electronic Annotation more info
involved_in intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info
involved_in microglia differentiation	IEA Inferred from Electronic Annotation more info
involved_in microglia differentiation	ISO Inferred from Sequence Orthology more info
involved_in microglia differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
involved_in myofibroblast contraction	IEA Inferred from Electronic Annotation more info
involved_in myofibroblast contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in spermatid development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spliceosome-depend formation of circular RNA	IEA Inferred from Electronic Annotation more info
involved_in spliceosome-depend formation of circular RNA	ISO Inferred from Sequence Orthology more info
involved_in spliceosome-depend formation of circular RNA	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular associated smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KH domain-containing RNA-binding protein QKI

Names: homolog of mouse quaking QKI (KH domain RNA binding protein); protein quaking; protein quaking-like; quaking; quaking, KH domain containing RNA binding; rqkI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115021.4 → NP_001108493.1 KH domain-containing RNA-binding protein QKI isoform 2

See identical proteins and their annotated locations for NP_001108493.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2JUS0, A0A8I6AP33, B0BNF5

Related

ENSRNOP00000023290.8, ENSRNOT00000023290.8

Conserved Domains (3) summary

PRK14951
Location:210 → 281

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

pfam16544
Location:10 → 66

STAR_dimer; Homodimerization region of STAR domain protein

cd22465
Location:81 → 183

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
NM_001414465.1 → NP_001401394.1 KH domain-containing RNA-binding protein QKI isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q91XU1

UniProtKB/TrEMBL

A0A0G2JXZ5

Related

ENSRNOP00000070460.2, ENSRNOT00000086441.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

52935357..53047338

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589896.3 → XP_017445385.2 KH domain-containing RNA-binding protein QKI isoform X1

UniProtKB/Swiss-Prot

Q91XU1

Conserved Domains (4) summary

PRK14950
Location:195 → 305

PRK14950; DNA polymerase III subunits gamma and tau; Provisional

pfam16544
Location:10 → 66

STAR_dimer; Homodimerization region of STAR domain protein

pfam16551
Location:304 → 333

Quaking_NLS; Putative nuclear localization signal of quaking

cd22465
Location:81 → 183

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
XM_039086917.2 → XP_038942845.1 KH domain-containing RNA-binding protein QKI isoform X3

UniProtKB/TrEMBL

A0A8I6AP33

Conserved Domains (3) summary

PRK14950
Location:195 → 289

PRK14950; DNA polymerase III subunits gamma and tau; Provisional

pfam16544
Location:10 → 66

STAR_dimer; Homodimerization region of STAR domain protein

cd22465
Location:81 → 183

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
XM_063270765.1 → XP_063126835.1 KH domain-containing RNA-binding protein QKI isoform X5

UniProtKB/TrEMBL

A0A8I6AP33, D4A2X0
XM_039086921.2 → XP_038942849.1 KH domain-containing RNA-binding protein QKI isoform X4

UniProtKB/TrEMBL

A0A8I6AP33

Conserved Domains (3) summary

PRK14951
Location:210 → 314

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

pfam16544
Location:10 → 66

STAR_dimer; Homodimerization region of STAR domain protein

cd22465
Location:81 → 183

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
XM_039086940.2 → XP_038942868.1 KH domain-containing RNA-binding protein QKI isoform X2

UniProtKB/TrEMBL

A0A8I6AP33

Related

ENSRNOP00000069203.3, ENSRNOT00000089149.3

Conserved Domains (3) summary

PRK14951
Location:210 → 281

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

pfam16544
Location:10 → 66

STAR_dimer; Homodimerization region of STAR domain protein

cd22465
Location:81 → 183

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
XM_039086942.2 → XP_038942870.1 KH domain-containing RNA-binding protein QKI isoform X7

UniProtKB/TrEMBL

A0A8I6AP33

Conserved Domains (3) summary

PRK14951
Location:210 → 281

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

pfam16544
Location:10 → 66

STAR_dimer; Homodimerization region of STAR domain protein

cd22465
Location:81 → 183

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
XM_039086927.2 → XP_038942855.1 KH domain-containing RNA-binding protein QKI isoform X6

UniProtKB/Swiss-Prot

Q91XU1

Conserved Domains (2) summary

pfam16551
Location:257 → 286

Quaking_NLS; Putative nuclear localization signal of quaking

cd22465
Location:26 → 128

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
XM_039086931.2 → XP_038942859.1 KH domain-containing RNA-binding protein QKI isoform X6

UniProtKB/Swiss-Prot

Q91XU1

Conserved Domains (2) summary

pfam16551
Location:257 → 286

Quaking_NLS; Putative nuclear localization signal of quaking

cd22465
Location:26 → 128

KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins