Cd151 CD151 molecule (Raph blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cd151provided by RGD
Full Name: CD151 molecule (Raph blood group)provided by RGD
Primary source: RGD:621290
See related: EnsemblRapid:ENSRNOG00000062573 AllianceGenome:RGD:621290
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables integrin binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including T cell proliferation; positive regulation of endocytosis; and wound healing, spreading of cells. Predicted to be located in basement membrane and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 798.4), Heart (RPKM 716.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205994300..205998307)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196564744..196568753)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214446659..214450668)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
Title: Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
CD151 Alleviates Early Blood-Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats.
Title: CD151 Alleviates Early Blood-Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats.
Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes.
Title: miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression.
Data indicate that the major contribution of cellular tetraspanins CD151 and Tspan8 to lymphatic metastasis formation relies on promoting motility and invasiveness.
Title: The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding.
CD151 and Tspan8 coordinately promote metastasis, where Tspan8 overrides the adhesive features of CD151 by recruiting integrins out of adhesion into motility promoting complexes.
Title: Tspan8 and CD151 promote metastasis by distinct mechanisms.
Expression of CD151 specifically attenuated adhesion-dependent activation of Ras.
Title: The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137382 (e-PCR)
- UniSTS:219470

BM391933 (e-PCR)
- UniSTS:249695

D1Bda71 (e-PCR)
- UniSTS:239822

Cd151 (e-PCR), detects polymorphism
- UniSTS:141267

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD151 antigen

Names: CD151 antigen (Raph blood group); CD151 antigen-like; PETA-3; platelet-endothelial tetraspan antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022523.1 → NP_071968.1 CD151 antigen

See identical proteins and their annotated locations for NP_071968.1

Status: PROVISIONAL

Source sequence(s)

AF192547

UniProtKB/Swiss-Prot

Q9QZA6

UniProtKB/TrEMBL

A0A8I6AQJ7, A6HXZ8

Conserved Domains (2) summary

cd03155
Location:112 → 220

CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:16 → 244

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205994300..205998307

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230576.5 → XP_006230638.1 CD151 antigen isoform X1

See identical proteins and their annotated locations for XP_006230638.1

UniProtKB/Swiss-Prot

Q9QZA6

UniProtKB/TrEMBL

A0A8I6AQJ7, A6HXZ8

Related

ENSRNOP00000096244.2, ENSRNOT00000107678.2

Conserved Domains (2) summary

cd03155
Location:112 → 220

CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:16 → 244

Tetraspannin; Tetraspanin family
XM_017589658.3 → XP_017445147.1 CD151 antigen isoform X1

UniProtKB/Swiss-Prot

Q9QZA6

UniProtKB/TrEMBL

A0A8I6AQJ7, A6HXZ8

Conserved Domains (2) summary

cd03155
Location:112 → 220

CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:16 → 244

Tetraspannin; Tetraspanin family