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    Rap1gap2 RAP1 GTPase activating protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303298, updated on 9-Dec-2024

    Summary

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    Symbol
    Rap1gap2provided by RGD
    Full Name
    RAP1 GTPase activating protein 2provided by RGD
    Primary source
    RGD:1304590
    See related
    EnsemblRapid:ENSRNOG00000002652 AllianceGenome:RGD:1304590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Garnl4
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of cell size. Predicted to act upstream of or within negative regulation of neuron projection development. Predicted to be located in several cellular components, including centrosome; cytosol; and nuclear membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 163.6), Brain (RPKM 161.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rap1gap2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (59753822..59970946, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59255400..59472536, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61177936..61395856, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 like 6 Neighboring gene olfactory receptor 1520 Neighboring gene ATP synthase subunit e, mitochondrial-like Neighboring gene coiled-coil domain containing 92B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rap1gap2 regulates axon outgrowth in olfactory sensory neurons. Sadrian B, et al. Mol Cell Neurosci, 2012 Jul. PMID 22732430
    2. Slp2-a controls renal epithelial cell size through regulation of Rap-ezrin signaling independently of Rab27. Yasuda T, et al. J Cell Sci, 2014 Feb 1. PMID 24284068
    3. Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Stork PJ, et al. Blood, 2005 Nov 1. PMID 16076873, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rap1 GTPase-activating protein 2
    Names
    GTPase activating RANGAP domain-like 4
    GTPase activating Rap/RanGAP domain-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401654.1 → NP_001388583.1  rap1 GTPase-activating protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K0S7, A0A8I6AH45
      Related
      ENSRNOP00000093453.2, ENSRNOT00000096456.2
      Conserved Domains (1) summary
      pfam02145
      Location:259 → 438
      Rap_GAP; Rap/ran-GAP

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      59753822..59970946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086002.1 → XP_038941930.1  rap1 GTPase-activating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3Q4
      Conserved Domains (1) summary
      pfam02145
      Location:340 → 519
      Rap_GAP; Rap/ran-GAP

    2. XM_017597289.1 → XP_017452778.1  rap1 GTPase-activating protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3Q4
      Related
      ENSRNOP00000094855.2, ENSRNOT00000113465.2

    3. XM_017597291.3 → XP_017452780.1  rap1 GTPase-activating protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A3Q4
      Related
      ENSRNOP00000087748.2, ENSRNOT00000112634.2

    4. XM_039086003.2 → XP_038941931.2  rap1 GTPase-activating protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A3Q4
      Related
      ENSRNOP00000060932.2, ENSRNOT00000065045.4

    5. XM_008767832.4 → XP_008766054.1  rap1 GTPase-activating protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZLX0, A0A8I6AH45
      Related
      ENSRNOP00000078969.1, ENSRNOT00000103095.2
      Conserved Domains (1) summary
      pfam02145
      Location:257 → 436
      Rap_GAP; Rap/ran-GAP

    6. XM_063269050.1 → XP_063125120.1  rap1 GTPase-activating protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AH45
      Related
      ENSRNOP00000092989.2, ENSRNOT00000094286.2

    7. XM_017597290.3 → XP_017452779.1  rap1 GTPase-activating protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZZT1, A0A8I6AH45
      Related
      ENSRNOP00000083327.1, ENSRNOT00000118524.2
      Conserved Domains (1) summary
      pfam02145
      Location:287 → 466
      Rap_GAP; Rap/ran-GAP

    8. XM_039086005.2 → XP_038941933.1  rap1 GTPase-activating protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AH45
      Conserved Domains (1) summary
      pfam02145
      Location:225 → 404
      Rap_GAP; Rap/ran-GAP

    9. XM_008767831.4 → XP_008766053.3  rap1 GTPase-activating protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQM4
      Related
      ENSRNOP00000096549.1, ENSRNOT00000106764.2

    10. XM_039086004.2 → XP_038941932.2  rap1 GTPase-activating protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AQM4

    RNA

    1. XR_005489831.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107019.1: Suppressed sequence

      Description
      NM_001107019.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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