Krt9 keratin 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt9provided by RGD
Official Full Name: keratin 9provided by RGD
Primary source: RGD:628785
See related: EnsemblRapid:ENSRNOG00000014370 AllianceGenome:RGD:628785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Krt1-9
Summary: Predicted to enable structural molecule activity. Involved in spermatogenesis. Located in keratin filament and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in epidermolytic palmoplantar keratoderma 1. Orthologous to human KRT9 (keratin 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (85621360..85627626, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85120962..85127228, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88102519..88107232, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BI294088 (e-PCR)
- UniSTS:246046

AU049096 (e-PCR)
- UniSTS:145544

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin development	IEA Inferred from Electronic Annotation more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: keratin, type I cytoskeletal 9

Names: CK-9; K9; cytokeratin-9; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; keratin complex 1, acidic, gene 9; spermatid perinuclear ring manchette protein K9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153476.2 → NP_703206.2 keratin, type I cytoskeletal 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

Related

ENSRNOP00000019330.5, ENSRNOT00000019330.8

Conserved Domains (1) summary

pfam00038
Location:138 → 450

Filament; Intermediate filament protein