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    Iqcg IQ motif containing G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iqcgprovided by RGD
    Official Full Name
    IQ motif containing Gprovided by RGD
    Primary source
    RGD:1311606
    See related
    EnsemblRapid:ENSRNOG00000026420 AllianceGenome:RGD:1311606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Hsp70 protein binding activity and calmodulin binding activity. Predicted to be involved in sperm axoneme assembly. Predicted to be located in actin cytoskeleton; manchette; and motile cilium. Predicted to be active in cytosol and sperm flagellum. Orthologous to human IQCG (IQ motif containing G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 103.8), Liver (RPKM 23.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iqcg in Genome Data Viewer
    Location:
    11q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81235204..81276249)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67730117..67771170)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70967228..71007708)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leishmanolysin like peptidase Neighboring gene ribosomal protein L35A Neighboring gene leucine rich repeats and calponin homology domain containing 3 Neighboring gene uncharacterized LOC134481085 Neighboring gene forty-two-three domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Iqcg is essential for sperm flagellum formation in mice. Li RK, et al. PLoS One, 2014. PMID 24849454, Free PMC Article
    2. IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. Harris TP, et al. G3 (Bethesda), 2014 Feb 19. PMID 24362311, Free PMC Article
    3. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Chen LT, et al. Nat Commun, 2014 May 2. PMID 24787902
    4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in manchette IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in manchette ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex protein 9
    Names
    IQ domain-containing protein G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014230.2 → NP_001014252.2  dynein regulatory complex protein 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q5PQQ6
      UniProtKB/TrEMBL
      A6IRM7, G3V973
      Related
      ENSRNOP00000071586.2, ENSRNOT00000087633.3

    2. NM_001433928.1 → NP_001420857.1  dynein regulatory complex protein 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q5PQQ6
      UniProtKB/TrEMBL
      A6IRM7, G3V973

    3. NM_001433929.1 → NP_001420858.1  dynein regulatory complex protein 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q5PQQ6
      UniProtKB/TrEMBL
      A6IRM7, G3V973

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81235204..81276249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248455.5 → XP_006248517.1  dynein regulatory complex protein 9 isoform X1

      Related
      ENSRNOP00000037862.4, ENSRNOT00000032518.6
      Conserved Domains (1) summary
      pfam04111
      Location:201 → 342
      APG6; Autophagy protein Apg6

    2. XM_006248456.5 → XP_006248518.1  dynein regulatory complex protein 9 isoform X1

      Conserved Domains (1) summary
      pfam04111
      Location:201 → 342
      APG6; Autophagy protein Apg6

    3. XM_039088545.2 → XP_038944473.1  dynein regulatory complex protein 9 isoform X2

      UniProtKB/TrEMBL
      A6IRM8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQQ6.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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