Fam161a FAM161 centrosomal protein A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam161aprovided by RGD
Official Full Name: FAM161 centrosomal protein Aprovided by RGD
Primary source: RGD:1304999
See related: EnsemblRapid:ENSRNOG00000009881 AllianceGenome:RGD:1304999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304999
Summary: Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in cilium assembly and positive regulation of protein acetylation. Located in ciliary basal body and photoreceptor connecting cilium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 28. Orthologous to human FAM161A (FAM161 centrosomal protein A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 208.3), Adrenal (RPKM 24.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (101210694..101256020)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (97009449..97027865)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (107785029..107803765)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM161A-associated RP can be considered as a novel retinal ciliopathy and that its molecular pathogenesis may be related to other ciliopathies.
Title: FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies.

Submit: New GeneRIF Correction

General gene information

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Markers

AW532997 (e-PCR)
- UniSTS:260685

RH134972 (e-PCR)
- UniSTS:218249

RH142897 (e-PCR)
- UniSTS:232144

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein acetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein acetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in astral microtubule	IEA Inferred from Electronic Annotation more info
located_in astral microtubule	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
colocalizes_with ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
colocalizes_with cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in photoreceptor cell cilium	ISO Inferred from Sequence Orthology more info
is_active_in photoreceptor connecting cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor connecting cilium	IEA Inferred from Electronic Annotation more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein FAM161A

Names: FAM161A, centrosomal protein; family with sequence similarity 161, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013876.2 → NP_001013898.2 protein FAM161A

Status: VALIDATED

Source sequence(s)

BC079233, CR470815, CV115343

UniProtKB/TrEMBL

A6JQ64

Related

ENSRNOP00000070570.3, ENSRNOT00000087091.3

Conserved Domains (1) summary

pfam10595
Location:170 → 492

UPF0564; uncharacterized protein family UPF0564

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

101210694..101256020

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599131.3 → XP_017454620.1 protein FAM161A isoform X1
XM_017599138.3 → XP_017454627.1 protein FAM161A isoform X4

UniProtKB/TrEMBL

A6JQ64

Related

ENSRNOP00000102948.1, ENSRNOT00000128400.1
XM_039091768.2 → XP_038947696.1 protein FAM161A isoform X7

Conserved Domains (1) summary

cl21461
Location:37 → 109

Globin-like; Globin-like protein superfamily
XM_017599132.3 → XP_017454621.1 protein FAM161A isoform X2

UniProtKB/TrEMBL

A0A8I5ZLY1

Related

ENSRNOP00000078780.1, ENSRNOT00000119794.2

Conserved Domains (1) summary

pfam10595
Location:170 → 527

UPF0564; uncharacterized protein family UPF0564
XM_063272986.1 → XP_063129056.1 protein FAM161A isoform X5

UniProtKB/TrEMBL

A0A8L2R4E5, A6JQ64
XM_063272987.1 → XP_063129057.1 protein FAM161A isoform X6

UniProtKB/TrEMBL

A0A0A0MXW0
XM_017599135.3 → XP_017454624.1 protein FAM161A isoform X3