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    Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4f18provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 18provided by RGD
    Primary source
    RGD:1305261
    See related
    EnsemblRapid:ENSRNOG00000015751 AllianceGenome:RGD:1305261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp4f3; CYPIVF3
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP4F3 (cytochrome P450 family 4 subfamily F member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 13.8), Uterus (RPKM 12.1) and 7 other tissues See more
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    Genomic context

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    See Cyp4f18 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17797558..17838958)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17763543..17804944)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19501680..19528935)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348385 Neighboring gene olfactory receptor pseudogene 1648 Neighboring gene zinc finger protein 617 Neighboring gene uncharacterized LOC102548752 Neighboring gene uncharacterized LOC134482464 Neighboring gene zinc finger protein 878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC124833

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 20-aldehyde-leukotriene B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 20-hydroxy-leukotriene B4 omega oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-1 hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid omega-1 hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-1 hydroxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid omega-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene B4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene B4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipoxin A4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoxin B4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in omega-hydroxylase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4F3
    Names
    cytochrome P450-LTB-omega
    leukotriene-B(4) 20-monooxygenase 2
    leukotriene-B(4) omega-1/omega-2 hydroxylase
    leukotriene-B(4) omega-hydroxylase 2
    NP_001028858.2
    NP_001380700.1
    XP_038950205.1
    XP_038950206.1
    XP_038950207.1
    XP_038950208.1
    XP_038950209.1
    XP_063131212.1
    XP_063131213.1
    XP_063131214.1
    XP_063131215.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033686.3 → NP_001028858.2  cytochrome P450 4F3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q3MID2
      UniProtKB/TrEMBL
      F1M7K8
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F

    2. NM_001393771.2 → NP_001380700.1  cytochrome P450 4F3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q3MID2
      UniProtKB/TrEMBL
      F1M7K8
      Related
      ENSRNOP00000098550.1, ENSRNOT00000120992.2
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17797558..17838958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275142.1 → XP_063131212.1  cytochrome P450 4F3 isoform X1

      UniProtKB/Swiss-Prot
      Q3MID2

    2. XM_039094281.2 → XP_038950209.1  cytochrome P450 4F3 isoform X5

      Conserved Domains (1) summary
      cl41757
      Location:74 → 359
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_063275143.1 → XP_063131213.1  cytochrome P450 4F3 isoform X2

    4. XM_039094280.1 → XP_038950208.1  cytochrome P450 4F3 isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:74 → 328
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    5. XM_063275145.1 → XP_063131215.1  cytochrome P450 4F3 isoform X6

    6. XM_063275144.1 → XP_063131214.1  cytochrome P450 4F3 isoform X3

      UniProtKB/TrEMBL
      A6K9R0

    7. XM_039094279.2 → XP_038950207.1  cytochrome P450 4F3 isoform X3

      UniProtKB/TrEMBL
      A6K9R0
      Conserved Domains (1) summary
      cl41757
      Location:1 → 366
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    8. XM_039094277.2 → XP_038950205.1  cytochrome P450 4F3 isoform X3

      UniProtKB/TrEMBL
      A6K9R0
      Conserved Domains (1) summary
      cl41757
      Location:1 → 366
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    9. XM_039094278.2 → XP_038950206.1  cytochrome P450 4F3 isoform X3

      UniProtKB/TrEMBL
      A6K9R0
      Conserved Domains (1) summary
      cl41757
      Location:1 → 366
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MID2.1 GenPept UniProtKB/Swiss-Prot:Q3MID2

    Gene LinkOut

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