Jak3 Janus kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jak3provided by RGD
Official Full Name: Janus kinase 3provided by RGD
Primary source: RGD:2940
See related: EnsemblRapid:ENSRNOG00000018669 AllianceGenome:RGD:2940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RATJAK3
Summary: Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and protein phosphatase binding activity. Involved in several processes, including positive regulation of activated T cell proliferation; positive regulation of calcium ion transport; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and endomembrane system. Predicted to be active in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Used to study graft-versus-host disease. Biomarker of tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe combined immunodeficiency. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 69.2), Thymus (RPKM 61.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18418807..18432515)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18386330..18398542)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20107471..20120678)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK-STAT signaling pathway by inhibiting JAK3.
Title: MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK-STAT signaling pathway by inhibiting JAK3.
Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report.
Title: Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report.
treatment downregulated the expression of JAK1, JAK3 and STAT3, and upregulated cytosolic nuclear factor (NF)kappaB p65 and IkappaB. In conclusion, the results of the present study indicated that curculigoside exhibited significant antiarthritic effects in vivo and in vitro, and the molecular mechanism may be associated with the JAK/STAT/NFkappaB signaling pathway.
Title: Curculigoside exerts significant anti‑arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF‑κB signaling pathway.
JAK3 mediates smooth muscle cell proliferation and survival during injury-induced vascular remodeling.
Title: Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling.
results showed that different JAK3 mutations induce constitutive activation through distinct mechanisms, pointing to specific therapeutic perspectives
Title: Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities.
Inhibition of the Jak3/Stat3 signaling pathway promotes apoptosis in a colon cancer model.
Title: Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy.
Secreted phospholipase PLA-IIA expression is regulated by the nitric oxide (NO)-JAK3-STAT1 pathway in microvascular endothelial cells of the injured brain.
Title: Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A₂-IIA in microvascular endothelial cells of the injured brain.
Both R507 and R545 are potent novel immunosuppressants with favorable pharmacokinetics and high JAK1/3 selectivity to reduce cardiac allograft rejection.
Title: Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
Berberine chloride has selectivity for JAK3 over other JAK kinase members.
Title: Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats.
JANEX-1 protects beta-cells from cytokine toxicity through suppression of the NF-kappaB and JAK/STAT pathways and upregulation of SOCS proteins, suggesting that JANEX-1 may be used to preserve functional beta-cell mass.
Title: JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

RH142198 (e-PCR)
- UniSTS:231448

D16RAT82 (e-PCR)
- UniSTS:121175

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in enzyme-linked receptor protein signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-4-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-7-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-7-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-9-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of FasL production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of FasL production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 1 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thymocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in response to interleukin-4	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK3

Names: JAK-3; Janus kinase 3, protein-tyrosine kinase

NP_036987.2

EC 2.7.10.2

XP_008769286.1

EC 2.7.10.2

XP_017455482.1

EC 2.7.10.2

XP_038950131.1

EC 2.7.10.2

XP_063131138.1

EC 2.7.10.2

XP_063131139.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012855.2 → NP_036987.2 tyrosine-protein kinase JAK3

See identical proteins and their annotated locations for NP_036987.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

F1LR79, Q63272

UniProtKB/TrEMBL

A0A8L2UK66

Conserved Domains (5) summary

cd13334
Location:250 → 359

FERM_C_JAK3; FERM domain C-lobe of Janus kinase (JAK) 3

pfam18377
Location:126 → 245

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:41 → 114

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:359 → 455

SH2; Src homology 2 (SH2) domain

cl21453
Location:813 → 1095

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18418807..18432515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275068.1 → XP_063131138.1 tyrosine-protein kinase JAK3 isoform X1

UniProtKB/Swiss-Prot

F1LR79, Q63272

UniProtKB/TrEMBL

A0A8L2UK66
XM_063275069.1 → XP_063131139.1 tyrosine-protein kinase JAK3 isoform X2

UniProtKB/TrEMBL

A0A8L2UK66
XM_008771064.4 → XP_008769286.1 tyrosine-protein kinase JAK3 isoform X1

See identical proteins and their annotated locations for XP_008769286.1

UniProtKB/Swiss-Prot

F1LR79, Q63272

UniProtKB/TrEMBL

A0A8L2UK66

Related

ENSRNOP00000025312.6, ENSRNOT00000025312.8

Conserved Domains (5) summary

cd13334
Location:250 → 359

FERM_C_JAK3; FERM domain C-lobe of Janus kinase (JAK) 3

pfam18377
Location:126 → 245

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:41 → 114

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:359 → 455

SH2; Src homology 2 (SH2) domain

cl21453
Location:813 → 1095

PKc_like; Protein Kinases, catalytic domain
XM_017599993.3 → XP_017455482.1 tyrosine-protein kinase JAK3 isoform X2

UniProtKB/TrEMBL

A0A8L2UK66
XM_039094203.2 → XP_038950131.1 tyrosine-protein kinase JAK3 isoform X1

UniProtKB/Swiss-Prot

F1LR79, Q63272

UniProtKB/TrEMBL

A0A8L2UK66

Conserved Domains (5) summary

cd13334
Location:250 → 359

FERM_C_JAK3; FERM domain C-lobe of Janus kinase (JAK) 3

pfam18377
Location:126 → 245

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:41 → 114

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:359 → 455

SH2; Src homology 2 (SH2) domain

cl21453
Location:813 → 1095

PKc_like; Protein Kinases, catalytic domain