Prg3 proteoglycan 3, pro eosinophil major basic protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prg3provided by RGD
Official Full Name: proteoglycan 3, pro eosinophil major basic protein 2provided by RGD
Primary source: RGD:1309904
See related: EnsemblRapid:ENSRNOG00000037908 AllianceGenome:RGD:1309904
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable carbohydrate binding activity. Predicted to be involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Orthologous to human PRG3 (proteoglycan 3, pro eosinophil major basic protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 129.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90478627..90484760)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (70071970..70078103)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72395194..72401254)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in basophil activation	ISO Inferred from Sequence Orthology more info
involved_in histamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proteoglycan 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106487.1 → NP_001099957.1 proteoglycan 3 precursor

See identical proteins and their annotated locations for NP_001099957.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HMS6, D4A834

Related

ENSRNOP00000054424.2, ENSRNOT00000057616.5

Conserved Domains (1) summary

cd03598
Location:110 → 225

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

90478627..90484760

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234449.3 → XP_006234511.1 proteoglycan 3 isoform X1

See identical proteins and their annotated locations for XP_006234511.1

UniProtKB/TrEMBL

A6HMS6, D4A834

Conserved Domains (1) summary

cd03598
Location:110 → 225

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
XM_006234450.3 → XP_006234512.1 proteoglycan 3 isoform X1

See identical proteins and their annotated locations for XP_006234512.1

UniProtKB/TrEMBL

A6HMS6, D4A834

Conserved Domains (1) summary

cd03598
Location:110 → 225

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)