Atp5mc3 ATP synthase membrane subunit c locus 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp5mc3provided by RGD
Official Full Name: ATP synthase membrane subunit c locus 3provided by RGD
Primary source: RGD:620052
See related: EnsemblRapid:ENSRNOG00000001596 AllianceGenome:RGD:620052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atp5g3
Summary: Enables ligand-gated channel activity. Involved in several processes, including pore complex assembly; response to (R)-carnitine; and response to muscle stretch. Part of cation channel complex. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia. Orthologous to human ATP5MC3 (ATP synthase membrane subunit c locus 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 6718.7), Muscle (RPKM 4018.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (79218014..79220664, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (58810535..58813185, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (60811218..60813903, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ligand-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pore complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to (R)-carnitine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle stretch	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase F(0) complex subunit C3, mitochondrial

Names: ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P3; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9); ATPase protein 9; ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361400.1 → NP_001348329.1 ATP synthase F(0) complex subunit C3, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

FN800719, JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AAH2, F7EW45, Q499S2

Related

ENSRNOP00000055032.3, ENSRNOT00000058234.5

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional
NM_001361401.1 → NP_001348330.1 ATP synthase F(0) complex subunit C3, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

FM058126, JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AAH2, F7EW45, Q499S2

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

79218014..79220664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_053756.1: Suppressed sequence

Description

NM_053756.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.