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    Ryr3 ryanodine receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ryr3provided by RGD
    Official Full Name
    ryanodine receptor 3provided by RGD
    Primary source
    RGD:68952
    See related
    EnsemblRapid:ENSRNOG00000006645 AllianceGenome:RGD:68952
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ryanodine-sensitive calcium-release channel activity. Involved in negative regulation of cytosolic calcium ion concentration and response to hypoxia. Located in cytoplasmic side of plasma membrane and perinuclear region of cytoplasm. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital myopathy 20 and hepatocellular carcinoma. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 73.2), Heart (RPKM 54.6) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ryr3 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    105
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119886129..120433465, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99431755..99979125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (104117307..104665151, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene proteasome subunit beta type-3-like Neighboring gene large ribosomal subunit protein eL30-like Neighboring gene uncharacterized LOC120101913 Neighboring gene uncharacterized LOC108350585 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120101454 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A polymorphism at the microRNA binding site in the 3' untranslated region of RYR3 is associated with outcome in hepatocellular carcinoma. Peng C, et al. Onco Targets Ther, 2015. PMID 26309413, Free PMC Article
    2. Contribution of ryanodine receptor subtype 3 to ca2+ responses in Ca2+-overloaded cultured rat portal vein myocytes. Mironneau J, et al. J Biol Chem, 2001 Apr 6. PMID 11150292
    3. Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells. Zheng YM, et al. J Gen Physiol, 2005 Apr. PMID 15795312, Free PMC Article
    4. Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia. Vanterpool CK, et al. J Appl Physiol (1985), 2006 Aug. PMID 16645194, Free PMC Article
    5. Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex. Bull R, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17360812

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
      Title: Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
    2. Expression levels of dihydropyridine alpha1c and RyR3 receptors in the rat diaphragm are unaffected during sepsis.
      Title: Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.
    3. In endoplasmic reticulum from brain cortex channel redox state determines RyR activation by Ca(2+) at physiological [ATP] and [Mg(2+)].
      Title: Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex.
    4. In PASMCs from RyR3 knockout mice, hypoxia-induced, but not submaximal noradrenaline-induced, Ca2+ release and contraction were significantly reduced.
      Title: Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells.
    5. These data suggest that advancing age selectively impacts the genetic expression and protein levels of RyR3 as well as modulatory nNOS protein levels. The function of RyRs may occur with the normal aging process.
      Title: Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-induced calcium release activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of junctional membrane complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ryanodine receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      119886129..120433465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284953.1 → XP_063141023.1  ryanodine receptor 3 isoform X6

      Related
      ENSRNOP00000100316.1, ENSRNOT00000146867.1

    2. XM_063284952.1 → XP_063141022.1  ryanodine receptor 3 isoform X5

      Related
      ENSRNOP00000107376.1, ENSRNOT00000122365.1

    3. XM_063284951.1 → XP_063141021.1  ryanodine receptor 3 isoform X4

      Related
      ENSRNOP00000040240.7, ENSRNOT00000049582.8

    4. XM_063284950.1 → XP_063141020.1  ryanodine receptor 3 isoform X3

    5. XM_063284955.1 → XP_063141025.1  ryanodine receptor 3 isoform X8

    6. XM_063284949.1 → XP_063141019.1  ryanodine receptor 3 isoform X2

      Related
      ENSRNOP00000106845.1, ENSRNOT00000040306.8

    7. XM_063284954.1 → XP_063141024.1  ryanodine receptor 3 isoform X7

    8. XM_063284948.1 → XP_063141018.1  ryanodine receptor 3 isoform X1

    9. XM_063284956.1 → XP_063141026.1  ryanodine receptor 3 isoform X9

    10. XM_063284957.1 → XP_063141027.1  ryanodine receptor 3 isoform X10

    11. XM_063284958.1 → XP_063141028.1  ryanodine receptor 3 isoform X11

    12. XM_063284959.1 → XP_063141029.1  ryanodine receptor 3 isoform X12

    RNA

    1. XR_010064867.1 RNA Sequence

    2. XR_010064868.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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