Pkdcc protein kinase domain containing, cytoplasmic [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pkdccprovided by RGD
Official Full Name: protein kinase domain containing, cytoplasmicprovided by RGD
Primary source: RGD:1311939
See related: AllianceGenome:RGD:1311939
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sgk493; RGD1311939
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including negative regulation of Golgi to plasma membrane protein transport; positive regulation of bone mineralization; and positive regulation of chondrocyte differentiation. Predicted to act upstream of or within bone mineralization and limb morphogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular region. Orthologous to human PKDCC (protein kinase domain containing, cytoplasmic). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 176.9), Liver (RPKM 161.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (17208171..17217488, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (11455686..11465002, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (6427657..6436974)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: extracellular tyrosine-protein kinase PKDCC

Names: protein kinase domain-containing protein, cytoplasmic; protein kinase-like protein SgK493; sugen kinase 493

NP_001101477.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108007.1 → NP_001101477.1 extracellular tyrosine-protein kinase PKDCC

See identical proteins and their annotated locations for NP_001101477.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6H9N4, B2GV56

Conserved Domains (1) summary

cl21453
Location:1 → 166

PKc_like; Protein Kinases, catalytic domain