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    A1bg alpha-1-B glycoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140656, updated on 27-Dec-2024

    Summary

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    Official Symbol
    A1bgprovided by RGD
    Official Full Name
    alpha-1-B glycoproteinprovided by RGD
    Primary source
    RGD:69417
    See related
    EnsemblRapid:ENSRNOG00000004692 AllianceGenome:RGD:69417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C44
    Summary
    Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within growth hormone receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human A1BG (alpha-1-B glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 3425.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See A1bg in Genome Data Viewer
    Location:
    7q33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (94383333..94387922, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (92493934..92498460, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (102294805..102298522, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene LRAT domain containing 2 Neighboring gene uncharacterized LOC134479737 Neighboring gene growth hormone inducible transmembrane protein, pseudogene 1 Neighboring gene uncharacterized LOC120093668 Neighboring gene uncharacterized LOC120093667 Neighboring gene uncharacterized LOC120093670 Neighboring gene uncharacterized LOC103692925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel growth hormone-regulated rat complementary deoxyribonucleic acid with homology to the human alpha1B-glycoprotein, characterizing a new protein family. Gardmo C, et al. Endocrinology, 2001 Jun. PMID 11356721
    2. Identification and characterization of differentially expressed genes in the early response phase during liver regeneration. Xu W, et al. Biochem Biophys Res Commun, 2000 Nov 19. PMID 11097837
    3. Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. Ishioka N, et al. Proc Natl Acad Sci U S A, 1986 Apr. PMID 3458201, Free PMC Article
    4. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Barallobre-Barreiro J, et al. Circulation, 2016 Sep 13. PMID 27559042, Free PMC Article
    5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in growth hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1B-glycoprotein
    Names
    liver regeneration-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022258.3 → NP_071594.3  alpha-1B-glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5EBD6, Q9EPH1, Q9JKL2
      UniProtKB/TrEMBL
      A0A8I6A5Z6, A6HRN5
      Related
      ENSRNOP00000006273.4, ENSRNOT00000006273.8
      Conserved Domains (3) summary
      pfam13895
      Location:233 → 311
      Ig_2; Immunoglobulin domain
      cd00096
      Location:29 → 33
      Ig; Ig strand A [structural motif]
      cl11960
      Location:29 → 125
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      94383333..94387922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078317.2 → XP_038934245.1  alpha-1B-glycoprotein isoform X1

      UniProtKB/TrEMBL
      A6HRN6
      Conserved Domains (3) summary
      pfam13895
      Location:233 → 311
      Ig_2; Immunoglobulin domain
      cd00096
      Location:29 → 33
      Ig; Ig strand A [structural motif]
      cl11960
      Location:29 → 125
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPH1.2 GenPept UniProtKB/Swiss-Prot:Q9EPH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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