Tle3 TLE family member 3, transcriptional corepressor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tle3provided by RGD
Official Full Name: TLE family member 3, transcriptional corepressorprovided by RGD
Primary source: RGD:620292
See related: EnsemblRapid:ENSRNOG00000013013 AllianceGenome:RGD:620292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Esp3
Summary: Predicted to enable transcription corepressor activity. Involved in regulation of DNA-templated transcription. Located in nucleus. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 84.5), Adrenal (RPKM 70.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (70753182..70799080)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (61857791..61903505)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (66296509..66342186)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Tle3 (e-PCR), detects polymorphism
- UniSTS:507281

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 3

Names: rTLE3; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3 homolog of Drosophila; transducin-like enhancer of split 3, E(spl) homolog; transducin-like enhancer of split 3, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053400.2 → NP_445852.1 transducin-like enhancer protein 3

See identical proteins and their annotated locations for NP_445852.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9JIT3

UniProtKB/TrEMBL

A0A8I5ZNN2, A6J560

Related

ENSRNOP00000018467.7, ENSRNOT00000018467.8

Conserved Domains (4) summary

cd00200
Location:476 → 761

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 464

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:481 → 520

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

70753182..70799080

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766347.4 → XP_008764569.1 transducin-like enhancer protein 3 isoform X1

See identical proteins and their annotated locations for XP_008764569.1

UniProtKB/TrEMBL

A0A8I5ZNN2

Related

ENSRNOP00000079710.2, ENSRNOT00000108424.2

Conserved Domains (4) summary

cd00200
Location:494 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 482

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:499 → 538

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006243214.5 → XP_006243276.1 transducin-like enhancer protein 3 isoform X5

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

COG2319
Location:483 → 775

WD40; WD40 repeat [General function prediction only]

cd00200
Location:489 → 774

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:494 → 533

7WD40; WD40 repeat [structural motif]
XM_006243213.5 → XP_006243275.1 transducin-like enhancer protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZNN2

Related

ENSRNOP00000109823.1, ENSRNOT00000164911.1

Conserved Domains (4) summary

COG2319
Location:485 → 777

WD40; WD40 repeat [General function prediction only]

cd00200
Location:491 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]
XM_006243215.5 → XP_006243277.1 transducin-like enhancer protein 3 isoform X6

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

COG2319
Location:480 → 772

WD40; WD40 repeat [General function prediction only]

cd00200
Location:486 → 771

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:491 → 530

7WD40; WD40 repeat [structural motif]
XM_006243212.5 → XP_006243274.1 transducin-like enhancer protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

COG2319
Location:487 → 779

WD40; WD40 repeat [General function prediction only]

cd00200
Location:493 → 778

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:498 → 537

7WD40; WD40 repeat [structural motif]
XM_063266230.1 → XP_063122300.1 transducin-like enhancer protein 3 isoform X4

UniProtKB/TrEMBL

A0A8I5ZNN2
XM_063266231.1 → XP_063122301.1 transducin-like enhancer protein 3 isoform X7

UniProtKB/TrEMBL

A0A8I5ZNN2
XM_006243216.5 → XP_006243278.1 transducin-like enhancer protein 3 isoform X8

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

cd00200
Location:484 → 769

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 472

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:489 → 528

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006243219.5 → XP_006243281.1 transducin-like enhancer protein 3 isoform X12

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

cd00200
Location:479 → 764

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 467

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006243218.5 → XP_006243280.1 transducin-like enhancer protein 3 isoform X10

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

cd00200
Location:481 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 469

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006243217.5 → XP_006243279.1 transducin-like enhancer protein 3 isoform X9

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

COG2319
Location:477 → 769

WD40; WD40 repeat [General function prediction only]

cd00200
Location:483 → 768

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:488 → 527

7WD40; WD40 repeat [structural motif]
XM_006243220.5 → XP_006243282.1 transducin-like enhancer protein 3 isoform X13

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

COG2319
Location:472 → 764

WD40; WD40 repeat [General function prediction only]

cd00200
Location:478 → 763

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:483 → 522

7WD40; WD40 repeat [structural motif]
XM_006243221.5 → XP_006243283.1 transducin-like enhancer protein 3 isoform X14

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

cd00200
Location:475 → 760

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:250 → 463

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:480 → 519

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_063266234.1 → XP_063122304.1 transducin-like enhancer protein 3 isoform X12

UniProtKB/TrEMBL

A0A8I5ZNN2
XM_006243211.5 → XP_006243273.1 transducin-like enhancer protein 3 isoform X1

See identical proteins and their annotated locations for XP_006243273.1

UniProtKB/TrEMBL

A0A8I5ZNN2

Conserved Domains (4) summary

cd00200
Location:494 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 482

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:499 → 538

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_063266232.1 → XP_063122302.1 transducin-like enhancer protein 3 isoform X10

UniProtKB/TrEMBL

A0A8I5ZNN2
XM_063266233.1 → XP_063122303.1 transducin-like enhancer protein 3 isoform X11

UniProtKB/TrEMBL

A0A8I5ZNN2