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    Ing5 inhibitor of growth family, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ing5provided by RGD
    Official Full Name
    inhibitor of growth family, member 5provided by RGD
    Primary source
    RGD:1307908
    See related
    EnsemblRapid:ENSRNOG00000018988 AllianceGenome:RGD:1307908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in several processes, including DNA replication-dependent chromatin disassembly; positive regulation of apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of fibroblast proliferation and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 82.8), Spleen (RPKM 78.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ing5 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101772845..101793734)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94326549..94343392)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100932932..100950233)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene deoxythymidylate kinase Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene galactose-3-O-sulfotransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5. Zhang H, et al. Cell Mol Biol Lett, 2019. PMID 31844418, Free PMC Article
    2. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Shiseki M, et al. Cancer Res, 2003 May 15. PMID 12750254
    3. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. Lalonde ME, et al. Genes Dev, 2013 Sep 15. PMID 24065767, Free PMC Article
    4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Ullah M, et al. Mol Cell Biol, 2008 Nov. PMID 18794358, Free PMC Article
    5. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One, 2011. PMID 21750715, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394332.1 → NP_001381261.1  inhibitor of growth protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6A7T0, B2RZ71, F7F3G6
      Related
      ENSRNOP00000062509.4, ENSRNOT00000065058.5
      Conserved Domains (2) summary
      cd15685
      Location:187 → 235
      PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
      cd16863
      Location:12 → 104
      ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101772845..101793734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267473.1 → XP_063123543.1  inhibitor of growth protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T0
      Related
      ENSRNOP00000107811.1, ENSRNOT00000133252.1

    2. XM_063267475.1 → XP_063123545.1  inhibitor of growth protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7T0

    3. XM_063267474.1 → XP_063123544.1  inhibitor of growth protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7T0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108810.1: Suppressed sequence

      Description
      NM_001108810.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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