Aqp2 aquaporin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp2provided by RGD
Official Full Name: aquaporin 2provided by RGD
Primary source: RGD:2142
See related: EnsemblRapid:ENSRNOG00000054378 AllianceGenome:RGD:2142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AQP-2; aquaporin-2
Summary: Enables PDZ domain binding activity; actin binding activity; and water transmembrane transporter activity. Involved in several processes, including actin filament depolymerization; cellular response to water deprivation; and response to glucagon. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and trans-Golgi network. Part of protein-containing complex. Used to study diabetes insipidus. Biomarker of hypertension and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic diabetes insipidus type 2. Orthologous to human AQP2 (aquaporin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 615.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132590286..132595321)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130711433..130716468)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141237802..141242837)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

'Aquaporin-omics': mechanisms of aquaporin-2 loss in polyuric disorders.
Title: 'Aquaporin-omics': mechanisms of aquaporin-2 loss in polyuric disorders.
Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rats.
Title: Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rats.
AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFkappaB-p65 Pathway Following Intracerebral Hemorrhage.
Title: AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFκB-p65 Pathway Following Intracerebral Hemorrhage.
Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy.
Title: Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy.
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
Title: Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
Release of ATP by TRPV4 activation is dependent upon the expression of AQP2 in renal cells.
Title: Release of ATP by TRPV4 activation is dependent upon the expression of AQP2 in renal cells.
Organ Specific Differences in Alteration of Aquaporin Expression in Rats Treated with Sennoside A, Senna Anthraquinones and Rhubarb Anthraquinones.
Title: Organ Specific Differences in Alteration of Aquaporin Expression in Rats Treated with Sennoside A, Senna Anthraquinones and Rhubarb Anthraquinones.
Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct.
Title: Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct.
Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease.
Title: Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease.
Direct effect of protein kinase A on four putative phosphorylation sites of aquaporin 2 in vitro.
Title: Direct effect of protein kinase A on four putative phosphorylation sites of aquaporin 2 in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94449 (e-PCR)
- UniSTS:119697

Aqp2 (e-PCR), detects polymorphism
- UniSTS:209563

RH134997 (e-PCR)
- UniSTS:218274

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables glycerol transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glycerol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IEA Inferred from Electronic Annotation more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	TAS Traceable Author Statement more info	PubMed
enables water transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mercury ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to water deprivation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to water deprivation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to water deprivation	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in glycerol transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric collecting duct development	IEA Inferred from Electronic Annotation more info
involved_in metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within renal water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in renal water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in renal water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal water transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal water transport	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucagon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in water transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in water transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in exocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in lumenal side of membrane	IEA Inferred from Electronic Annotation more info
located_in lumenal side of membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aquaporin-2

Names: ADH water channel; AQP-CD; WCH-CD; aquaporin 2 (collecting duct); aquaporin-CD; collecting duct water channel protein; water channel protein for renal collecting duct

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012909.3 → NP_037041.3 aquaporin-2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

A1A5L4, P34080

UniProtKB/TrEMBL

A6KCG0

Related

ENSRNOP00000074297.2, ENSRNOT00000091717.3

Conserved Domains (1) summary

pfam00230
Location:3 → 219

MIP; Major intrinsic protein