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    Bmal1 basic helix-loop-helix ARNT like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29657, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bmal1provided by RGD
    Official Full Name
    basic helix-loop-helix ARNT like 1provided by RGD
    Primary source
    RGD:62003
    See related
    EnsemblRapid:ENSRNOG00000014448 AllianceGenome:RGD:62003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arntl
    Summary
    The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in Thymus (RPKM 162.2), Liver (RPKM 123.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bmal1 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (176766222..176864741)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167331756..167430235)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178039002..178137469)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton-associated protein 2, pseudogene 3 Neighboring gene uncharacterized LOC120099909 Neighboring gene BTB domain containing 10 Neighboring gene uncharacterized LOC134484822 Neighboring gene RNA, U6 small nuclear 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables E-box binding  
    enables E-box binding  
    enables E-box binding  
    enables Hsp90 protein binding  
    enables Hsp90 protein binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables aryl hydrocarbon receptor binding  
    enables aryl hydrocarbon receptor binding  
    enables bHLH transcription factor binding  
    enables protein dimerization activity  
    enables protein heterodimerization activity  
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables transcription coregulator activity  
    Items 1 - 25 of 28
    Items 1 - 25 of 67
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian rhythm  
    involved_in circadian rhythm PubMed 
    acts_upstream_of_or_within circadian rhythm  
    involved_in circadian rhythm  
    involved_in energy homeostasis  
    acts_upstream_of_or_within gene expression  
    involved_in maternal process involved in parturition  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of glucocorticoid receptor signaling pathway  
    involved_in negative regulation of glucocorticoid receptor signaling pathway  
    involved_in oxidative stress-induced premature senescence  
    involved_in oxidative stress-induced premature senescence  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of skeletal muscle cell differentiation  
    involved_in positive regulation of skeletal muscle cell differentiation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein import into nucleus  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cellular senescence  
    involved_in regulation of cellular senescence  
    involved_in regulation of hair cycle  
    involved_in regulation of hair cycle  
    involved_in regulation of hair cycle  
    involved_in regulation of insulin secretion  
    involved_in regulation of insulin secretion  
    involved_in regulation of neurogenesis  
    involved_in regulation of neurogenesis  
    acts_upstream_of_or_within regulation of protein catabolic process  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of type B pancreatic cell development  
    involved_in regulation of type B pancreatic cell development  
    involved_in response to redox state  
    involved_in response to redox state  
    involved_in response to redox state  
    involved_in rhythmic process  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    Items 1 - 25 of 67
    Component Evidence Code Pubs
    part_of CLOCK-BMAL transcription complex  
    part_of CLOCK-BMAL transcription complex  
    located_in PML body  
    part_of aryl hydrocarbon receptor complex  
    located_in chromatoid body  
    located_in chromatoid body  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in intracellular membrane-bounded organelle  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex  
    part_of transcription regulator complex  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    basic helix-loop-helix ARNT-like protein 1
    Names
    aryl hydrocarbon receptor nuclear translocator-like protein 1
    brain and muscle ARNT-like 1
    tic

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024362.2NP_077338.2  basic helix-loop-helix ARNT-like protein 1

      See identical proteins and their annotated locations for NP_077338.2

      Status: VALIDATED

      Source sequence(s)
      BC099833
      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A6I877, D3ZT62
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      cd11438
      Location:67130
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:339441
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      176766222..176864741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230029.5XP_006230091.1  basic helix-loop-helix ARNT-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006230091.1

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A6I877, D3ZT62
      Related
      ENSRNOP00000042830.3, ENSRNOT00000046313.6
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      cd11438
      Location:67130
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:339441
      PAS_11; PAS domain
    2. XM_017589065.3XP_017444554.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A0A8I5ZXD2, A6I875
      Conserved Domains (3) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd11438
      Location:74137
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:346448
      PAS_11; PAS domain
    3. XM_017589068.3XP_017444557.1  basic helix-loop-helix ARNT-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      Conserved Domains (3) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd11438
      Location:74137
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:345447
      PAS_11; PAS domain
    4. XM_006230030.5XP_006230092.1  basic helix-loop-helix ARNT-like protein 1 isoform X4

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      Conserved Domains (3) summary
      smart00091
      Location:149208
      PAS; PAS domain
      cd11438
      Location:67130
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:338440
      PAS_11; PAS domain
    5. XM_039109748.2XP_038965676.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A0A8I5ZXD2, A6I875
      Conserved Domains (3) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd11438
      Location:74137
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:346448
      PAS_11; PAS domain
    6. XM_063287814.1XP_063143884.1  basic helix-loop-helix ARNT-like protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A6I877, D3ZT62
    7. XM_017589067.3XP_017444556.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A0A8I5ZXD2, A6I875
      Conserved Domains (3) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd11438
      Location:74137
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:346448
      PAS_11; PAS domain
    8. XM_039109755.2XP_038965683.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A0A8I5ZXD2, A6I875
      Conserved Domains (3) summary
      smart00091
      Location:156215
      PAS; PAS domain
      cd11438
      Location:74137
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:346448
      PAS_11; PAS domain
    9. XM_063287804.1XP_063143874.1  basic helix-loop-helix ARNT-like protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A6I877, D3ZT62
    10. XM_063287791.1XP_063143861.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A0A8I5ZXD2, A6I875
      Related
      ENSRNOP00000082167.1, ENSRNOT00000095012.2
    11. XM_017589070.3XP_017444559.1  basic helix-loop-helix ARNT-like protein 1 isoform X6

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      UniProtKB/TrEMBL
      A0A8I6A2N7
      Related
      ENSRNOP00000087129.1, ENSRNOT00000097013.2
      Conserved Domains (3) summary
      smart00091
      Location:106165
      PAS; PAS domain
      cd11438
      Location:2487
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:296398
      PAS_11; PAS domain
    12. XM_039109788.2XP_038965716.1  basic helix-loop-helix ARNT-like protein 1 isoform X7

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      Conserved Domains (3) summary
      smart00091
      Location:106165
      PAS; PAS domain
      cd11438
      Location:2487
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:295397
      PAS_11; PAS domain
    13. XM_039109778.1XP_038965706.1  basic helix-loop-helix ARNT-like protein 1 isoform X5

      UniProtKB/Swiss-Prot
      O88337, O88810, Q499M8, Q9EPW1
      Conserved Domains (3) summary
      smart00091
      Location:132191
      PAS; PAS domain
      cd11438
      Location:50113
      bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
      pfam14598
      Location:322424
      PAS_11; PAS domain
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