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    Cmc2 C-x(9)-C motif containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100363376, updated on 9-Dec-2024

    Summary

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    Symbol
    Cmc2provided by RGD
    Full Name
    C-x(9)-C motif containing 2provided by RGD
    Primary source
    RGD:2324599
    See related
    EnsemblRapid:ENSRNOG00000068690 AllianceGenome:RGD:2324599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in mitochondrion. Orthologous to human CMC2 (C-X9-C motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 244.5), Heart (RPKM 156.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmc2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (61852126..61880768, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (44943283..44971930, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (49433332..49457641, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene dynein light chain roadblock-type 2 Neighboring gene chromodomain Y-like 2 Neighboring gene uncharacterized LOC134483651 Neighboring gene centromere protein N Neighboring gene ATM interactor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Horn D, et al. J Biol Chem, 2010 May 14. PMID 20220131, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COX assembly mitochondrial protein 2 homolog
    Names
    rCG51296-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402209.1 → NP_001389138.1  COX assembly mitochondrial protein 2 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZF8, D4A471

    2. NM_001402210.1 → NP_001389139.1  COX assembly mitochondrial protein 2 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZF8, D4A471
      Related
      ENSRNOP00000087382.1, ENSRNOT00000095441.2

    3. NM_001402211.1 → NP_001389140.1  COX assembly mitochondrial protein 2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZLA6
      Related
      ENSRNOP00000078459.1, ENSRNOT00000117703.2

    4. NM_001402212.1 → NP_001389141.1  COX assembly mitochondrial protein 2 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZF8, D4A471

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      61852126..61880768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098177.2 → XP_038954105.1  COX assembly mitochondrial protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6IZF8, D4A471
      Conserved Domains (1) summary
      pfam08583
      Location:1 → 70
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
    Nucleotide Protein Strain
    Heading Accession and Version

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