Pomgnt1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pomgnt1provided by RGD
Official Full Name: protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)provided by RGD
Primary source: RGD:1359396
See related: EnsemblRapid:ENSRNOG00000023455 AllianceGenome:RGD:1359396
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Predicted to be involved in O-glycan processing. Predicted to act upstream of or within several processes, including nervous system development; protein O-linked mannosylation; and reactive gliosis. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in lissencephaly; muscular dystrophy (multiple); and retinitis pigmentosa. Orthologous to human POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 99.0), Muscle (RPKM 98.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134870971..134880864)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129634274..129644150)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135007343..135017220)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_7377-7378:992008389:1 (e-PCR)
- UniSTS:231328

MARC_7377-7378:996687832:1 (e-PCR)
- UniSTS:231328

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in O-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in O-glycan processing	IEA Inferred from Electronic Annotation more info
involved_in O-glycan processing	ISO Inferred from Sequence Orthology more info
involved_in O-glycan processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in basement membrane organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in dentate gyrus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in localization of cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within localization of cell	ISO Inferred from Sequence Orthology more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked mannosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein O-linked mannosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein modification process	ISO Inferred from Sequence Orthology more info
involved_in reactive gliosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reactive gliosis	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Names: O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase

NP_001007748.1

EC 2.4.1.-

XP_006238745.1

EC 2.4.1.-

XP_063144049.1

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007747.1 → NP_001007748.1 protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

See identical proteins and their annotated locations for NP_001007748.1

Status: PROVISIONAL

Source sequence(s)

BC083641

UniProtKB/Swiss-Prot

Q5XIN7

UniProtKB/TrEMBL

A0A8L2QK62

Related

ENSRNOP00000035825.6, ENSRNOT00000035312.7

Conserved Domains (2) summary

cd02514
Location:301 → 628

GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides

cd13937
Location:99 → 246

PANDER_GnT-1_2_like; PANDER-like domain of N-acetylglucosaminyltransferases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

134870971..134880864

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287979.1 → XP_063144049.1 protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q5XIN7

UniProtKB/TrEMBL

A0A8L2QK62
XM_006238683.5 → XP_006238745.1 protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform X2

See identical proteins and their annotated locations for XP_006238745.1

UniProtKB/TrEMBL

A0A8I6AMP8, A0A8L2QK62, A6JZ66

Related

ENSRNOP00000095021.1, ENSRNOT00000109490.2

Conserved Domains (2) summary

cd02514
Location:279 → 606

GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides

cd13937
Location:77 → 224

PANDER_GnT-1_2_like; PANDER-like domain of N-acetylglucosaminyltransferases