Rgma repulsive guidance molecule BMP co-receptor a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgmaprovided by RGD
Official Full Name: repulsive guidance molecule BMP co-receptor aprovided by RGD
Primary source: RGD:1311983
See related: EnsemblRapid:ENSRNOG00000012874 AllianceGenome:RGD:1311983
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable coreceptor activity and transferrin receptor binding activity. Involved in negative regulation of axon regeneration; negative regulation of collateral sprouting; and positive regulation of neuron projection development. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in plasma membrane. Used to study middle cerebral artery infarction. Biomarker of middle cerebral artery infarction; sciatic neuropathy; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 53.1), Uterus (RPKM 40.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (136538782..136582763)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (127128934..127172918)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (134699053..134742512)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats.
Title: Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats.
Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity.
Title: Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity.
RGMa promotes reactive astrogliosis and glial scar formation by forming a complex with ALK5 and Smad2/3 to promote ALK5-Smad2/3 interaction to facilitate TGFbeta1/Smad2/3 signaling, thereby inhibiting neurological functional recovery.
Title: RGMa mediates reactive astrogliosis and glial scar formation through TGFβ1/Smad2/3 signaling after stroke.
RGMa might suppress angiogenesis via VEGF, Ang2, Ang1 and BDNF after cerebral ischemia/reperfusion injury
Title: Repulsive guidance molecule a suppresses angiogenesis after ischemia/reperfusion injury of middle cerebral artery occlusion in rats.
Overexpression of RGMa inhibited hyper-excitability of hippocampal neurons.
Title: Lentiviral Vector-Induced Overexpression of RGMa in the Hippocampus Suppresses Seizures and Mossy Fiber Sprouting.
the RGMaFAKRas pathway may be involved in MFS and the development of temporal lobe epilepsy.
Title: Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model.
this study suggests that RGMa regulates the proper axonal branching of hippocampal mossy fibers
Title: Repulsive guidance molecule a regulates hippocampal mossy fiber branching in vitro.
RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3beta signaling pathways.
Title: CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo.
Minocycline-induced down-regulation of RGMa expression was associated with enhanced axonal regeneration after cerebral ischemia-reperfusion.
Title: Minocycline promotes axonal regeneration through suppression of RGMa in rat MCAO/reperfusion model.
we concluded that RGMa could be another key molecule and might inhibit axonal regeneration during cerebral ischemia/reperfusion injury
Title: Fastigial nucleus electrostimulation reduces the expression of repulsive guidance molecule, improves axonal growth following focal cerebral ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

Rgma (e-PCR), detects polymorphism
- UniSTS:508017

AA819234 (e-PCR)
- UniSTS:243441

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: repulsive guidance molecule A

Names: RGM domain family, member A; repulsive guidance molecule family member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107524.1 → NP_001100994.1 repulsive guidance molecule A precursor

See identical proteins and their annotated locations for NP_001100994.1

Status: PROVISIONAL

Source sequence(s)

CH473980

UniProtKB/TrEMBL

A6JBX6, A6JBX8, D4A188

Related

ENSRNOP00000061067.1, ENSRNOT00000068766.4

Conserved Domains (2) summary

pfam06534
Location:227 → 405

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:48 → 222

RGM_N; Repulsive guidance molecule (RGM) N-terminus