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    Gdap2 ganglioside-induced differentiation-associated-protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gdap2provided by RGD
    Official Full Name
    ganglioside-induced differentiation-associated-protein 2provided by RGD
    Primary source
    RGD:1306050
    See related
    EnsemblRapid:ENSRNOG00000019754 AllianceGenome:RGD:1306050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within response to retinoic acid. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 149.3), Brain (RPKM 87.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gdap2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (190217158..190276128)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (187528514..187585270)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (202470485..202526849)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 17 Neighboring gene Set nuclear proto-oncogene, pseudogene 9 Neighboring gene WD repeat domain 3 Neighboring gene uncharacterized LOC120100896 Neighboring gene terminal nucleotidyltransferase 5C Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mannosidase, alpha, class 1A, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. Liu H, et al. J Neurochem, 1999 May. PMID 10217254
    2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ganglioside-induced differentiation-associated-protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013201.1 → NP_001013219.1  ganglioside-induced differentiation-associated-protein 2

      See identical proteins and their annotated locations for NP_001013219.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082000
      UniProtKB/Swiss-Prot
      Q66H63
      UniProtKB/TrEMBL
      A0A8L2QEA9
      Conserved Domains (2) summary
      cd02905
      Location:55 → 222
      Macro_GDAP2-like; macrodomain, GDAP2-like family
      pfam13716
      Location:349 → 480
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      190217158..190276128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282173.1 → XP_063138243.1  ganglioside-induced differentiation-associated-protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QEA9
      Related
      ENSRNOP00000087653.1, ENSRNOT00000102364.2

    2. XM_006233032.5 → XP_006233094.1  ganglioside-induced differentiation-associated-protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006233094.1

      UniProtKB/Swiss-Prot
      Q66H63
      UniProtKB/TrEMBL
      A0A8L2QEA9
      Related
      ENSRNOP00000026953.7, ENSRNOT00000026953.9
      Conserved Domains (2) summary
      cd02905
      Location:55 → 222
      Macro_GDAP2-like; macrodomain, GDAP2-like family
      pfam13716
      Location:349 → 480
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H63.1 GenPept UniProtKB/Swiss-Prot:Q66H63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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