Adprhl1 ADP-ribosylhydrolase like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Adprhl1provided by RGD
Full Name: ADP-ribosylhydrolase like 1provided by RGD
Primary source: RGD:1305641
See related: EnsemblRapid:ENSRNOG00000071336 AllianceGenome:RGD:1305641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07026536.1
Summary: Predicted to enable ADP-ribosylarginine hydrolase activity and magnesium ion binding activity. Predicted to be involved in cardiac chamber ballooning and cardiac myofibril assembly. Predicted to be located in sarcomere. Orthologous to human ADPRHL1 (ADP-ribosylhydrolase like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 271.3), Muscle (RPKM 109.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82985355..83017240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76283186..76315075)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81616098..81648133)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP-ribosylarginine hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac chamber ballooning	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac myofibril assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein de-ADP-ribosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in sarcomere	IEA Inferred from Electronic Annotation more info
located_in sarcomere	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inactive ADP-ribosyltransferase ARH2

Names: ADP-ribosylhydrolase 2; ADP-ribosylhydrolase-like protein 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013054.2 → NP_001013072.1 inactive ADP-ribosyltransferase ARH2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q5XIB3

UniProtKB/TrEMBL

A0A8L2QE10, A6IWI7

Conserved Domains (1) summary

pfam03747
Location:6 → 326

ADP_ribosyl_GH; ADP-ribosylglycohydrolase
NM_001409008.1 → NP_001395937.1 inactive ADP-ribosyltransferase ARH2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8J8XAN4

Related

ENSRNOP00000054552.6, ENSRNOT00000057740.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

82985355..83017240

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275261.1 → XP_063131331.1 inactive ADP-ribosyltransferase ARH2 isoform X1
XM_039095253.2 → XP_038951181.1 inactive ADP-ribosyltransferase ARH2 isoform X1

Conserved Domains (1) summary

PHA03247
Location:949 → 1315

PHA03247; large tegument protein UL36; Provisional