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    Crls1 cardiolipin synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366196, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crls1provided by RGD
    Official Full Name
    cardiolipin synthase 1provided by RGD
    Primary source
    RGD:1311037
    See related
    EnsemblRapid:ENSRNOG00000021273 AllianceGenome:RGD:1311037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311037
    Summary
    Enables cardiolipin synthase (CMP-forming). Involved in response to phosphatidylethanolamine and response to thyroxine. Located in mitochondrial membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 247.2), Kidney (RPKM 226.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Crls1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140572680..140591543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120119822..120138674)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125503638..125522460)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene leucine rich repeat neuronal 4 Neighboring gene FERM domain containing kindlin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cardiolipin synthase (CMP-forming)  
    enables cardiolipin synthase (CMP-forming) PubMed 
    enables cardiolipin synthase (CMP-forming)  
    enables cardiolipin synthase (CMP-forming)  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    located_in mitochondrial membrane PubMed 
    is_active_in mitochondrion  
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    cardiolipin synthase (CMP-forming)
    Names
    CLS
    cardiolipin synthetase
    NP_001014280.1
    XP_006235140.1
    XP_006235141.1
    XP_006235142.1
    XP_063140355.1
    XP_063140356.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014258.1NP_001014280.1  cardiolipin synthase (CMP-forming)

      See identical proteins and their annotated locations for NP_001014280.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085849
      UniProtKB/Swiss-Prot
      Q5U2V5
      UniProtKB/TrEMBL
      A6HQH5
      Related
      ENSRNOP00000028900.5, ENSRNOT00000028900.8
      Conserved Domains (1) summary
      COG0558
      Location:107297
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140572680..140591543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284285.1XP_063140355.1  cardiolipin synthase (CMP-forming) isoform X3

    2. XM_006235080.5XP_006235142.1  cardiolipin synthase (CMP-forming) isoform X2

      See identical proteins and their annotated locations for XP_006235142.1

      Conserved Domains (1) summary
      PLN02794
      Location:1174
      PLN02794; cardiolipin synthase
    3. XM_006235078.5XP_006235140.1  cardiolipin synthase (CMP-forming) isoform X1

      See identical proteins and their annotated locations for XP_006235140.1

      Conserved Domains (1) summary
      PLN02794
      Location:10189
      PLN02794; cardiolipin synthase
    4. XM_006235079.5XP_006235141.1  cardiolipin synthase (CMP-forming) isoform X2

      See identical proteins and their annotated locations for XP_006235141.1

      Conserved Domains (1) summary
      PLN02794
      Location:1174
      PLN02794; cardiolipin synthase
    5. XM_063284286.1XP_063140356.1  cardiolipin synthase (CMP-forming) isoform X2

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