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    Atp6v0a4 ATPase H+ transporting V0 subunit a4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp6v0a4provided by RGD
    Official Full Name
    ATPase H+ transporting V0 subunit a4provided by RGD
    Primary source
    RGD:1305055
    See related
    EnsemblRapid:ENSRNOG00000013428 AllianceGenome:RGD:1305055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase binding activity. Predicted to be involved in several processes, including sensory perception of sound; synaptic vesicle lumen acidification; and vacuolar acidification. Predicted to act upstream of or within proton transmembrane transport. Located in apical plasma membrane. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 558.7) and Brain (RPKM 31.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v0a4 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67727145..67809092, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66760163..66842126, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65736585..65821916, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene tripartite motif-containing 24 Neighboring gene SVOP like Neighboring gene uncharacterized LOC134486756 Neighboring gene transmembrane protein 213 Neighboring gene KIAA1549 homolog Neighboring gene ZC3HAV1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Smith AN, et al. Nat Genet, 2000 Sep. PMID 10973252
    2. Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene. Smith AN, et al. J Biol Chem, 2001 Nov 9. PMID 11495928
    3. Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis. Stehberger PA, et al. J Am Soc Nephrol, 2003 Dec. PMID 14638902
    4. Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. Stover EH, et al. J Med Genet, 2002 Nov. PMID 12414817, Free PMC Article
    5. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Petrovic S, et al. Am J Physiol Renal Physiol, 2006 May. PMID 16352747

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal tubular secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase 116 kDa subunit a 4
    Names
    ATPase, H+ transporting, lysosomal V0 subunit A
    ATPase, H+ transporting, lysosomal V0 subunit A4
    V-type proton ATPase 116 kDa subunit a
    NP_001402767.1
    XP_063141818.1
    XP_063141819.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415838.1 → NP_001402767.1  V-type proton ATPase 116 kDa subunit a 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IER1, D4A1H0
      Related
      ENSRNOP00000061018.2, ENSRNOT00000064201.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      67727145..67809092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285748.1 → XP_063141818.1  V-type proton ATPase 116 kDa subunit a 4 isoform X1

      UniProtKB/TrEMBL
      A6IER1, D4A1H0

    2. XM_063285749.1 → XP_063141819.1  V-type proton ATPase 116 kDa subunit a 4 isoform X1

      UniProtKB/TrEMBL
      A6IER1, D4A1H0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106591.1: Suppressed sequence

      Description
      NM_001106591.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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