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    Spire1 spire-type actin nucleation factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spire1provided by RGD
    Official Full Name
    spire-type actin nucleation factor 1provided by RGD
    Primary source
    RGD:1305892
    See related
    EnsemblRapid:ENSRNOG00000025324 AllianceGenome:RGD:1305892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of mitochondrial fission. Predicted to act upstream of or within behavioral fear response and dendritic spine development. Predicted to be located in several cellular components, including Golgi apparatus; cleavage furrow; and mitochondrial outer membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 215.9), Adrenal (RPKM 109.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spire1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63311800..63441545, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61041914..61171670, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63226557..63357420, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 7-like Neighboring gene PRELI domain containing 3A Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene centrosomal protein 76 Neighboring gene proteasome assembly chaperone 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis. Wen Q, et al. Cell Death Dis, 2018 Feb 12. PMID 29434191, Free PMC Article
    2. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Manor U, et al. Elife, 2015 Aug 25. PMID 26305500, Free PMC Article
    3. Enhanced fear expression in Spir-1 actin organizer mutant mice. Pleiser S, et al. Eur J Cell Biol, 2014 May-Jun. PMID 24345451
    4. The Spir actin organizers are involved in vesicle transport processes. Kerkhoff E, et al. Curr Biol, 2001 Dec 11. PMID 11747823
    5. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Belin BJ, et al. Elife, 2015 Aug 19. PMID 26287480, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spire 1 is an ES regulator to support germ cell development during spermatogenesis.
      Title: Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of meiotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of meiotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formin-nucleated actin cable assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polar body extrusion after meiotic divisions IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polar body extrusion after meiotic divisions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein spire homolog 1
    Names
    spire homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415681.1 → NP_001402610.1  protein spire homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JZR0, A6IXV4, D3ZEX7
      Related
      ENSRNOP00000062729.1, ENSRNOT00000066103.4

    2. NM_001415682.1 → NP_001402611.1  protein spire homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6B5T2, A6IXV3

    3. NM_001415684.1 → NP_001402613.1  protein spire homolog 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXV3
      Related
      ENSRNOP00000097454.2, ENSRNOT00000108704.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63311800..63441545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600946.3 → XP_017456435.1  protein spire homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6IXV4, D3ZEX7

    2. XM_006254860.5 → XP_006254922.1  protein spire homolog 1 isoform X1

      UniProtKB/TrEMBL
      A6IXV4, D3ZEX7
      Related
      ENSRNOP00000071145.3, ENSRNOT00000089408.3
      Conserved Domains (2) summary
      cd15767
      Location:630 → 750
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24 → 220
      KIND; Kinase non-catalytic C-lobe domain

    3. XM_063277313.1 → XP_063133383.1  protein spire homolog 1 isoform X4

      UniProtKB/TrEMBL
      A6IXV4, D3ZEX7

    4. XM_039096794.2 → XP_038952722.1  protein spire homolog 1 isoform X3

      UniProtKB/TrEMBL
      A6IXV4, D3ZEX7
      Related
      ENSRNOP00000096614.2, ENSRNOT00000112905.2
      Conserved Domains (6) summary
      cd15767
      Location:537 → 657
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cd22065
      Location:151 → 182
      WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
      cd22078
      Location:191 → 222
      WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
      cd22080
      Location:256 → 279
      WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
      cl21453
      Location:14 → 127
      PKc_like; Protein Kinases, catalytic domain
      cl41728
      Location:225 → 247
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    5. XM_063277314.1 → XP_063133384.1  protein spire homolog 1 isoform X5

      UniProtKB/TrEMBL
      A6IXV4, D3ZEX7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107381.1: Suppressed sequence

      Description
      NM_001107381.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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