Mettl18 methyltransferase 18, RPL3 N3(tau)-histidine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl18provided by RGD
Official Full Name: methyltransferase 18, RPL3 N3(tau)-histidineprovided by RGD
Primary source: RGD:1306783
See related: EnsemblRapid:ENSRNOG00000025189 AllianceGenome:RGD:1306783
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306783
Summary: Predicted to enable heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Predicted to be involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Predicted to be located in cytosol and nucleolus. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 77.9), Liver (RPKM 53.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (78879053..78881226)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76345888..76348798)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (82298534..82300763)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein-L-histidine N-tele-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-L-histidine N-tele-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-L-histidine N-tele-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptidyl-lysine monomethylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine monomethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ribosome biogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribosome biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translational elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational elongation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histidine protein methyltransferase 1 homolog

Names: methyltransferase 18, RPL3 N3-histidine; methyltransferase like 18; methyltransferase-like protein 18

NP_001020839.1

EC 2.1.1.85

XP_006250217.1

EC 2.1.1.85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025668.1 → NP_001020839.1 histidine protein methyltransferase 1 homolog

See identical proteins and their annotated locations for NP_001020839.1

Status: PROVISIONAL

Source sequence(s)

BC098702

UniProtKB/Swiss-Prot

Q4KM84

UniProtKB/TrEMBL

A6IDD0

Conserved Domains (1) summary

cl17173
Location:155 → 314

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

78879053..78881226

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250155.5 → XP_006250217.1 histidine protein methyltransferase 1 homolog isoform X1

See identical proteins and their annotated locations for XP_006250217.1

UniProtKB/Swiss-Prot

Q4KM84

UniProtKB/TrEMBL

A6IDD0

Related

ENSRNOP00000110677.1, ENSRNOT00000157956.1

Conserved Domains (1) summary

cl17173
Location:155 → 314

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...