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    Thnsl1 threonine synthase-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thnsl1provided by RGD
    Official Full Name
    threonine synthase-like 1provided by RGD
    Primary source
    RGD:1564213
    See related
    EnsemblRapid:ENSRNOG00000033076 AllianceGenome:RGD:1564213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human THNSL1 (threonine synthase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 61.9), Brain (RPKM 61.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thnsl1 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (88623054..88630681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (83714794..83722190)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (88095830..88102264)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550221 Neighboring gene uncharacterized LOC134482761 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene ribosomal protein S8 like 1 Neighboring gene G protein-coupled receptor 158 Neighboring gene uncharacterized LOC102549062

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    threonine synthase-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025035.1 → NP_001020206.1  threonine synthase-like 1

      See identical proteins and their annotated locations for NP_001020206.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091213
      UniProtKB/TrEMBL
      Q5BK42
      Related
      ENSRNOP00000106210.1, ENSRNOT00000165785.1
      Conserved Domains (4) summary
      cd01560
      Location:230 → 733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK00131
      Location:56 → 223
      aroK; shikimate kinase; Reviewed
      PRK09225
      Location:231 → 739
      PRK09225; threonine synthase; Validated
      cd00464
      Location:57 → 204
      SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      88623054..88630681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096029.2 → XP_038951957.1  threonine synthase-like 1 isoform X1

      UniProtKB/TrEMBL
      E9PTK4
      Related
      ENSRNOP00000054444.2, ENSRNOT00000045984.6
      Conserved Domains (2) summary
      cd01560
      Location:230 → 733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      pfam01202
      Location:64 → 221
      SKI; Shikimate kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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