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    Apcdd1 APC down-regulated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apcdd1provided by RGD
    Official Full Name
    APC down-regulated 1provided by RGD
    Primary source
    RGD:1589962
    See related
    EnsemblRapid:ENSRNOG00000043304 AllianceGenome:RGD:1589962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Wnt-protein binding activity and identical protein binding activity. Predicted to be involved in hair follicle development; negative regulation of Wnt signaling pathway; and regulation of odontogenesis of dentin-containing tooth. Predicted to act upstream of or within astrocyte cell migration. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypotrichosis 1. Orthologous to human APCDD1 (APC down-regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 260.9), Brain (RPKM 85.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apcdd1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58655696..58686359)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (56385398..56416065)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (58270398..58300982)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348798 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483041 Neighboring gene NSF attachment protein gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The role of APCDD1 in epithelial rearrangement in tooth morphogenesis. Neupane S, et al. Histochem Cell Biol, 2015 Oct. PMID 26170146
    2. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Shimomura Y, et al. Nature, 2010 Apr 15. PMID 20393562, Free PMC Article
    3. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Kang P, et al. Neuron, 2012 Apr 12. PMID 22500632, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within astrocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    APC down-regulated 1; protein APCDD1
    Names
    adenomatosis polyposis coli down-regulated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432563.1 → NP_001419492.1  APC down-regulated 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXL1, F1M5Q7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      58655696..58686359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001071384.5 → XP_001071384.2  protein APCDD1

      Related
      ENSRNOP00000059242.2, ENSRNOT00000067554.5
      Conserved Domains (1) summary
      pfam14921
      Location:51 → 282
      APCDDC; Adenomatosis polyposis coli down-regulated 1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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