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    Fastkd5 FAST kinase domains 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366192, updated on 9-Dec-2024

    Summary

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    Symbol
    Fastkd5provided by RGD
    Full Name
    FAST kinase domains 5provided by RGD
    Primary source
    RGD:1563839
    See related
    EnsemblRapid:ENSRNOG00000053270 AllianceGenome:RGD:1563839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563839; Fastkd5-ps1; AABR07053741.1
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial RNA processing. Predicted to be located in mitochondrial nucleoid and ribonucleoprotein granule. Orthologous to human FASTKD5 (FAST kinase domains 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 80.7), Thymus (RPKM 76.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fastkd5 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138283315..138300803, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117830219..117847707, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123154263..123170615, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene oxytocin/neurophysin I prepropeptide Neighboring gene arginine vasopressin Neighboring gene U-box domain containing 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Antonicka H, et al. Cell Rep, 2015 Feb 17. PMID 25683715
    2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 5, mitochondrial
    Names
    FAST kinase domains 5, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399367.1 → NP_001386296.1  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AAM0
      Conserved Domains (3) summary
      smart00952
      Location:699 → 758
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:431 → 500
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:512 → 601
      FAST_2; FAST kinase-like protein, subdomain 2

    2. NM_001399368.1 → NP_001386297.1  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AAM0
      Related
      ENSRNOP00000089567.1, ENSRNOT00000117848.2
      Conserved Domains (3) summary
      smart00952
      Location:699 → 758
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:431 → 500
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:512 → 601
      FAST_2; FAST kinase-like protein, subdomain 2

    3. NM_001399369.1 → NP_001386298.1  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AAM0
      Conserved Domains (3) summary
      smart00952
      Location:699 → 758
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:431 → 500
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:512 → 601
      FAST_2; FAST kinase-like protein, subdomain 2

    4. NM_001399370.1 → NP_001386299.1  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AAM0
      Related
      ENSRNOP00000100700.1, ENSRNOT00000170345.1
      Conserved Domains (3) summary
      smart00952
      Location:699 → 758
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:431 → 500
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:512 → 601
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138283315..138300803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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