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    Rasgef1a RasGEF domain family, member 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasgef1aprovided by RGD
    Official Full Name
    RasGEF domain family, member 1Aprovided by RGD
    Primary source
    RGD:1305836
    See related
    EnsemblRapid:ENSRNOG00000031671 AllianceGenome:RGD:1305836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cell migration; and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGEF1A (RasGEF domain family member 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 197.9) and Lung (RPKM 111.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasgef1a in Genome Data Viewer
    Location:
    4q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (152859900..152940365)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (151187533..151267982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (150063484..150144203)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene H2A.Z histone variant 2 like 1 Neighboring gene uncharacterized LOC120102376 Neighboring gene uncharacterized LOC134486839 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene developmental pluripotency-associated 3, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. Ura K, et al. Clin Cancer Res, 2006 Nov 15. PMID 17121879
    2. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. Yaman E, et al. FEBS J, 2009 Aug. PMID 19645719
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-GEF domain-containing family member 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431730.1 → NP_001418659.1  ras-GEF domain-containing family member 1A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6G621, D3ZZV7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      152859900..152940365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237211.5 → XP_006237273.1  ras-GEF domain-containing family member 1A isoform X2

      Conserved Domains (2) summary
      cd06224
      Location:49 → 167
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:217 → 411
      RasGEF; RasGEF domain

    2. XM_063286976.1 → XP_063143046.1  ras-GEF domain-containing family member 1A isoform X2

      UniProtKB/TrEMBL
      A0A8I6G621, D3ZZV7

    3. XM_232315.10 → XP_232315.7  ras-GEF domain-containing family member 1A isoform X1

      UniProtKB/TrEMBL
      D3ZZV7
      Related
      ENSRNOP00000100659.1, ENSRNOT00000170936.1

    4. XM_039108790.2 → XP_038964718.1  ras-GEF domain-containing family member 1A isoform X2

      UniProtKB/TrEMBL
      A0A8I6G621, D3ZZV7
      Related
      ENSRNOP00000080031.1, ENSRNOT00000096843.2
      Conserved Domains (2) summary
      cd06224
      Location:49 → 167
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:217 → 411
      RasGEF; RasGEF domain
    Nucleotide Protein Strain
    Heading Accession and Version

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