Aars1 alanyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aars1provided by RGD
Official Full Name: alanyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1304832
See related: EnsemblRapid:ENSRNOG00000018404 AllianceGenome:RGD:1304832
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aars
Summary: Enables several functions, including ATP binding activity; alanine-tRNA ligase activity; and tRNA binding activity. Involved in alanyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; leukodystrophy; and trichothiodystrophy. Orthologous to human AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 469.9), Brain (RPKM 328.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (55906694..55930499)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (38999130..39021152)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (43193264..43215281, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH66606 (e-PCR)
- UniSTS:19748

RH137129 (e-PCR)
- UniSTS:219217

AI316495 (e-PCR)
- UniSTS:179820

RH126058 (e-PCR)
- UniSTS:162770

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IPI Inferred from Physical Interaction more info	PubMed
enables Ser-tRNA(Ala) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables Ser-tRNA(Ala) hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables alanine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables amino acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables aminoacyl-tRNA editing activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacyl-tRNA editing activity	ISO Inferred from Sequence Orthology more info
enables aminoacyl-tRNA editing activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide lactyltransferase (ATP-dependent) activity	ISO Inferred from Sequence Orthology more info
enables peptide lactyltransferase (ATP-dependent) activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in alanyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within alanyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in alanyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellar Purkinje cell layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoplasmic translational fidelity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: alanine--tRNA ligase, cytoplasmic

Names: alaRS; alanyl-tRNA synthetase, cytoplasmic; protein lactyltransferase AARS1

NP_001093987.1

EC 6.1.1.7

XP_006255644.1

EC 6.1.1.7

XP_006255645.1

EC 6.1.1.7

XP_063134010.1

EC 6.1.1.7

XP_063134011.1

EC 6.1.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100517.2 → NP_001093987.1 alanine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_001093987.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057

Conserved Domains (1) summary

PLN02900
Location:6 → 961

PLN02900; alanyl-tRNA synthetase
NM_001434414.1 → NP_001421343.1 alanine--tRNA ligase, cytoplasmic

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057
NM_001434415.1 → NP_001421344.1 alanine--tRNA ligase, cytoplasmic

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057
NM_001434416.1 → NP_001421345.1 alanine--tRNA ligase, cytoplasmic

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

55906694..55930499

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277940.1 → XP_063134010.1 alanine--tRNA ligase, cytoplasmic isoform X1

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057

Related

ENSRNOP00000025051.5, ENSRNOT00000025052.7
XM_006255583.5 → XP_006255645.1 alanine--tRNA ligase, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_006255645.1

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057

Conserved Domains (1) summary

PLN02900
Location:6 → 961

PLN02900; alanyl-tRNA synthetase
XM_063277941.1 → XP_063134011.1 alanine--tRNA ligase, cytoplasmic isoform X1

UniProtKB/Swiss-Prot

A6IZ80, P50475, Q4G057
XM_006255582.5 → XP_006255644.1 alanine--tRNA ligase, cytoplasmic isoform X1

Conserved Domains (1) summary

PLN02900
Location:6 → 961

PLN02900; alanyl-tRNA synthetase