Abraxas2 abraxas 2, BRISC complex subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abraxas2provided by RGD
Official Full Name: abraxas 2, BRISC complex subunitprovided by RGD
Primary source: RGD:1308918
See related: EnsemblRapid:ENSRNOG00000017222 AllianceGenome:RGD:1308918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam175b; RGD1308918
Summary: Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including nuclear chromosome segregation; protein K63-linked deubiquitination; and response to ischemia. Predicted to act upstream of or within cellular response to freezing. Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. Predicted to be part of BRISC complex. Predicted to be active in nucleus. Orthologous to human ABRAXAS2 (abraxas 2, BRISC complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 126.2), Adrenal (RPKM 124.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (197077177..197102753)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (187647078..187672660)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (204861768..204887344)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EST-CFZ97746 (e-PCR)
- UniSTS:263450

RH129099 (e-PCR)
- UniSTS:212407

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to freezing	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BRISC complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in microtubule minus-end	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BRISC complex subunit Abraxas 2

Names: BRISC complex subunit Abro1; family with sequence similarity 175, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.