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    Chtf18 chromosome transmission fidelity factor 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287146, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chtf18provided by RGD
    Official Full Name
    chromosome transmission fidelity factor 18provided by RGD
    Primary source
    RGD:1310473
    See related
    EnsemblRapid:ENSRNOG00000019174 AllianceGenome:RGD:1310473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within germ cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Predicted to be located in cytosol; male germ cell nucleus; and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 38.6), Spleen (RPKM 27.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Chtf18 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15247525..15255573, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14743006..14751044, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15090762..15098825, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene lipase maturation factor 1 Neighboring gene uncharacterized LOC120095315 Neighboring gene G protein subunit gamma 13 Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene mesothelin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables DNA binding  
    contributes_to DNA clamp loader activity  
    contributes_to DNA clamp loader activity  
    contributes_to single-stranded DNA helicase activity  
    contributes_to single-stranded DNA helicase activity  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in male germ cell nucleus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    chromosome transmission fidelity protein 18 homolog
    Names
    CTF18, chromosome transmission fidelity factor 18 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105773.1NP_001099243.1  chromosome transmission fidelity protein 18 homolog

      See identical proteins and their annotated locations for NP_001099243.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6ALU6, A6HD39, D4AC99
      Related
      ENSRNOP00000026139.8, ENSRNOT00000026139.8
      Conserved Domains (2) summary
      cd00009
      Location:345515
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cl19912
      Location:485552
      DNA_pol3_delta; DNA polymerase III, delta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15247525..15255573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245936.5XP_006245998.1  chromosome transmission fidelity protein 18 homolog isoform X1

      UniProtKB/TrEMBL
      D4AC99
      Related
      ENSRNOP00000089836.2, ENSRNOT00000099898.2
      Conserved Domains (2) summary
      cd00009
      Location:346516
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cl19912
      Location:486553
      DNA_pol3_delta; DNA polymerase III, delta subunit
    2. XM_017597066.3XP_017452555.1  chromosome transmission fidelity protein 18 homolog isoform X2

      UniProtKB/TrEMBL
      D4AC99
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