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    Plch2 phospholipase C, eta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plch2provided by RGD
    Official Full Name
    phospholipase C, eta 2provided by RGD
    Primary source
    RGD:1304675
    See related
    EnsemblRapid:ENSRNOG00000014226 AllianceGenome:RGD:1304675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304675
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including phosphatidylinositol-mediated signaling; phospholipase C-activating G protein-coupled receptor signaling pathway; and release of sequestered calcium ion into cytosol. Predicted to be located in plasma membrane. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 61.7), Lung (RPKM 8.1) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plch2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170826543..170885012, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165544209..165613769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172386400..172455965, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 14 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene MORN repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. Nakahara M, et al. J Biol Chem, 2005 Aug 12. PMID 15899900
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
    NP_001413979.1
    NP_001413980.1
    XP_008762618.2
    XP_017449377.1
    XP_017449380.1
    XP_038967300.1
    XP_038967301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427050.1 → NP_001413979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6GLE1

    2. NM_001427051.1 → NP_001413980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4AAX6
      Related
      ENSRNOP00000019096.7, ENSRNOT00000019096.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      170826543..170885012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764396.4 → XP_008762618.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLE1
      Related
      ENSRNOP00000095956.2, ENSRNOT00000115181.2

    2. XM_017593891.3 → XP_017449380.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

      UniProtKB/TrEMBL
      D4AAX6

    3. XM_017593888.3 → XP_017449377.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

      UniProtKB/TrEMBL
      D4AAX6

    4. XM_039111373.2 → XP_038967301.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

      Conserved Domains (4) summary
      cd08633
      Location:468 → 877
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02222
      Location:406 → 1017
      PLN02222; phosphoinositide phospholipase C 2
      cd13364
      Location:192 → 298
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16221
      Location:316 → 456
      EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

    5. XM_039111372.2 → XP_038967300.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

      Conserved Domains (4) summary
      cd08633
      Location:468 → 877
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02222
      Location:406 → 1017
      PLN02222; phosphoinositide phospholipase C 2
      cd13364
      Location:192 → 298
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16221
      Location:316 → 456
      EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

    RNA

    1. XR_005505150.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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