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    Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prkag3provided by RGD
    Official Full Name
    protein kinase AMP-activated non-catalytic subunit gamma 3provided by RGD
    Primary source
    RGD:1308698
    See related
    EnsemblRapid:ENSRNOG00000017248 AllianceGenome:RGD:1308698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ampkg3
    Summary
    Contributes to AMP-activated protein kinase activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to act upstream of or within negative regulation of glycogen biosynthetic process and response to muscle activity involved in regulation of muscle adaptation. Part of nucleotide-activated protein kinase complex. Orthologous to human PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 168.9), Heart (RPKM 18.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prkag3 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83744385..83753629, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76295715..76304959, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81999368..82008620, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene peptidylprolyl isomerase A, pseudogene 15 Neighboring gene Wnt family member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3. Yao C, et al. Mol Neurobiol, 2016 Oct. PMID 26399639
    2. Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Mahlapuu M, et al. Am J Physiol Endocrinol Metab, 2004 Feb. PMID 14559719
    3. 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. Barnes BR, et al. FASEB J, 2005 May. PMID 15857891
    4. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, et al. FEBS Lett, 2003 Jul 3. PMID 12829246
    5. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG. J Cell Sci, 2004 Nov 1. PMID 15509864

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-132 downregulated PRKAG3 through binding to its 3'-UTR, and PRKAG3 knockdown compromised the reducing effect of miR-132 inhibition on Schwann cell migration under normal or hypoxia condition.
      Title: Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3.
    2. the observation that the AMPKgamma3 isoform is expressed primarily in white skeletal muscle, in which it is the predominant gamma-isoform, strongly suggests that gamma3 has a key role in this tissue.
      Title: Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of carbon utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to muscle activity involved in regulation of muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-3
    Names
    AMP-activated protein kinase gamma 3 subunit
    protein kinase, AMP-activated, gamma 3 non-catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432481.1 → NP_001419410.1  5'-AMP-activated protein kinase subunit gamma-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JVW1, D4A7E4

    2. NM_001432485.1 → NP_001419414.1  5'-AMP-activated protein kinase subunit gamma-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JVW1, D4A7E4

    3. NM_001432486.1 → NP_001419415.1  5'-AMP-activated protein kinase subunit gamma-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JVW1, D4A7E4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83744385..83753629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266978.1 → XP_063123048.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X2

    2. XM_039083362.1 → XP_038939290.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X1

      Related
      ENSRNOP00000023365.6, ENSRNOT00000023365.7
      Conserved Domains (2) summary
      cd04618
      Location:192 → 329
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:355 → 478
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    3. XM_039083363.2 → XP_038939291.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X3

      Conserved Domains (2) summary
      cd04618
      Location:167 → 304
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:330 → 453
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    4. XM_039083364.2 → XP_038939292.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X4

      Conserved Domains (2) summary
      cd04618
      Location:1 → 111
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:137 → 260
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106921.1: Suppressed sequence

      Description
      NM_001106921.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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