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    Rabgap1 RAB GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rabgap1provided by RGD
    Official Full Name
    RAB GTPase activating protein 1provided by RGD
    Primary source
    RGD:1304691
    See related
    EnsemblRapid:ENSRNOG00000009402 AllianceGenome:RGD:1304691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be located in cytosol. Orthologous to human RABGAP1 (RAB GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 188.3), Brain (RPKM 178.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rabgap1 in Genome Data Viewer
    Location:
    3q11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41617784..41735795)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21208012..21326013)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21698032..21815383)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene G protein-coupled receptor 21 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134486087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article
    2. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107841.1 → NP_001101311.1  rab GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_001101311.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A0A8I5Y656, A6JET4, D3ZX42
      Related
      ENSRNOP00000013378.7, ENSRNOT00000013378.7
      Conserved Domains (4) summary
      smart00164
      Location:559 → 768
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:141 → 269
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:790 → 1016
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:303 → 433
      DUF3694; Kinesin protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41617784..41735795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105274.2 → XP_038961202.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y656, A6JET4, D3ZX42
      Conserved Domains (4) summary
      smart00164
      Location:559 → 768
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:141 → 269
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:790 → 1016
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:303 → 433
      DUF3694; Kinesin protein

    2. XM_039105276.2 → XP_038961204.1  rab GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      D3ZX42
      Conserved Domains (4) summary
      smart00164
      Location:541 → 750
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:123 → 251
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:772 → 998
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:285 → 415
      DUF3694; Kinesin protein

    3. XM_039105273.2 → XP_038961201.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y656, A6JET4, D3ZX42
      Conserved Domains (4) summary
      smart00164
      Location:559 → 768
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:141 → 269
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:790 → 1016
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:303 → 433
      DUF3694; Kinesin protein

    4. XM_039105277.2 → XP_038961205.1  rab GTPase-activating protein 1 isoform X3

      UniProtKB/TrEMBL
      D3ZX42
      Conserved Domains (4) summary
      smart00164
      Location:491 → 700
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:73 → 201
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:722 → 948
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:235 → 365
      DUF3694; Kinesin protein

    5. XM_039105275.2 → XP_038961203.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y656, A6JET4, D3ZX42
      Conserved Domains (4) summary
      smart00164
      Location:559 → 768
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:141 → 269
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:790 → 1016
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:303 → 433
      DUF3694; Kinesin protein

    6. XM_039105278.2 → XP_038961206.1  rab GTPase-activating protein 1 isoform X4

      UniProtKB/TrEMBL
      D3ZX42
      Related
      ENSRNOP00000076600.2, ENSRNOT00000110651.2
      Conserved Domains (4) summary
      smart00164
      Location:461 → 670
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:43 → 171
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:692 → 918
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:205 → 335
      DUF3694; Kinesin protein
    Nucleotide Protein Strain
    Heading Accession and Version

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