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    Akr1d1 aldo-keto reductase family 1, member D1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192242, updated on 9-Dec-2024

    Summary

    Official Symbol
    Akr1d1provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member D1provided by RGD
    Primary source
    RGD:620752
    See related
    EnsemblRapid:ENSRNOG00000013004 AllianceGenome:RGD:620752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3-oxo-5-beta-steroid 4-dehydrogenase activity. Predicted to be involved in several processes, including C21-steroid hormone metabolic process; androgen metabolic process; and cholesterol catabolic process. Predicted to act upstream of or within bile acid biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 2. Orthologous to human AKR1D1 (aldo-keto reductase family 1 member D1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2347.4) See more
    Orthologs
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    Genomic context

    See Akr1d1 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67121288..67154543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66154246..66187505)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65110706..65143930)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, iota Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene uncharacterized LOC134486755 Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene tripartite motif-containing 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-oxo-5-beta-steroid 4-dehydrogenase activity PubMed 
    enables Delta4-3-oxosteroid 5beta-reductase activity  
    enables aldose reductase (NADPH) activity  
    enables ketosteroid monooxygenase activity  
    enables steroid dehydrogenase activity  
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process  
    involved_in C21-steroid hormone metabolic process  
    involved_in androgen metabolic process  
    involved_in androgen metabolic process  
    involved_in androgen metabolic process  
    involved_in bile acid biosynthetic process  
    acts_upstream_of_or_within bile acid biosynthetic process  
    involved_in bile acid biosynthetic process  
    involved_in bile acid catabolic process  
    involved_in cholesterol catabolic process  
    involved_in cholesterol catabolic process  
    involved_in digestion  
    involved_in digestion  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    aldo-keto reductase family 1 member D1
    Names
    3-oxo-5-beta-steroid 4-dehydrogenase
    aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
    delta(4)-3-ketosteroid 5-beta-reductase
    delta(4)-3-oxosteroid 5-beta-reductase
    NP_620239.2
    XP_006236347.1
    XP_038962921.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138884.2NP_620239.2  aldo-keto reductase family 1 member D1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P31210
      UniProtKB/TrEMBL
      A0A8I5ZSN6, A6IEQ7
      Related
      ENSRNOP00000080261.1, ENSRNOT00000103598.2
      Conserved Domains (1) summary
      cd19109
      Location:15321
      AKR_AKR1D1-3; AKR1D family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      67121288..67154543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106993.2XP_038962921.1  aldo-keto reductase family 1 member D1 isoform X2

      UniProtKB/Swiss-Prot
      P31210
      Related
      ENSRNOP00000111180.1, ENSRNOT00000161889.1
      Conserved Domains (1) summary
      cl00470
      Location:15295
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    2. XM_006236285.3XP_006236347.1  aldo-keto reductase family 1 member D1 isoform X1

      UniProtKB/Swiss-Prot
      P31210
      UniProtKB/TrEMBL
      A0A0G2KAV5
      Related
      ENSRNOP00000075542.1, ENSRNOT00000083672.3
      Conserved Domains (2) summary
      COG0656
      Location:28297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:26289
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
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