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    Sharpin SHANK-associated RH domain interactor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81859, updated on 4-Jan-2025

    Summary

    Official Symbol
    Sharpinprovided by RGD
    Official Full Name
    SHANK-associated RH domain interactorprovided by RGD
    Primary source
    RGD:631353
    See related
    EnsemblRapid:ENSRNOG00000012812 AllianceGenome:RGD:631353
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Conneck1
    Summary
    Enables identical protein binding activity. Predicted to be involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; protein linear polyubiquitination; and regulation of signal transduction. Predicted to act upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SHARPIN (SHANK associated RH domain interactor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 163.7), Kidney (RPKM 146.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sharpin in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109951336..109955552, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108070681..108075012, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117413151..117417455, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene cytochrome c-1 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene WD repeat domain 97

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93373

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables metal ion binding  
    enables polyubiquitin modification-dependent protein binding  
    enables polyubiquitin modification-dependent protein binding  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables protein-macromolecule adaptor activity  
    enables ubiquitin binding  
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic nuclear changes  
    involved_in defense response to bacterium  
    involved_in defense response to bacterium  
    acts_upstream_of_or_within epidermis development  
    acts_upstream_of_or_within keratinization  
    acts_upstream_of_or_within mitochondrion organization  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein linear polyubiquitination  
    involved_in protein linear polyubiquitination  
    involved_in protein linear polyubiquitination  
    involved_in regulation of CD40 signaling pathway  
    involved_in regulation of CD40 signaling pathway  
    involved_in regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in regulation of tumor necrosis factor-mediated signaling pathway  
    Component Evidence Code Pubs
    part_of LUBAC complex  
    part_of LUBAC complex  
    part_of LUBAC complex  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in postsynaptic density PubMed 

    General protein information

    Preferred Names
    sharpin
    Names
    SHANK-associated RH domain interacting protein
    shank-associated RH domain-interacting protein
    shank-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031153.2NP_112415.1  sharpin

      See identical proteins and their annotated locations for NP_112415.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083553
      UniProtKB/Swiss-Prot
      Q9EQL9
      UniProtKB/TrEMBL
      A6HS86
      Related
      ENSRNOP00000018032.3, ENSRNOT00000018031.6
      Conserved Domains (4) summary
      sd00029
      Location:346365
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:215299
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam00641
      Location:346370
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam16764
      Location:18125
      Sharpin_PH; Sharpin PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109951336..109955552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079946.2XP_038935874.1  sharpin isoform X1

      UniProtKB/Swiss-Prot
      Q9EQL9
      UniProtKB/TrEMBL
      A6HS86
      Conserved Domains (4) summary
      sd00029
      Location:346365
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:215299
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam00641
      Location:346370
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam16764
      Location:18125
      Sharpin_PH; Sharpin PH domain
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