C3ar1 complement C3a receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C3ar1provided by RGD
Official Full Name: complement C3a receptor 1provided by RGD
Primary source: RGD:620537
See related: EnsemblRapid:ENSRNOG00000009211 AllianceGenome:RGD:620537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables complement component C3a binding activity and complement component C3a receptor activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of cell population proliferation; and tolerance induction to nonself antigen. Predicted to be active in plasma membrane. Used to study adult respiratory distress syndrome. Biomarker of asthma and lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 15.4), Kidney (RPKM 15.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157747419..157756609, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (156074747..156084680, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155681767..155691240, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats.
Title: C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats.
Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.
Title: Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.
C3aRA ameliorated T2DN by inhibiting IKBalpha phosphorylation and cytokine release, and also TGF-beta/Smad3 signaling and ECM deposition
Title: C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.
C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations
Title: Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
The C3 and C3a receptor system may primarily be involved in the pathogenesis of renal remodeling in hypertensive rats.
Title: Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.
The binding of TLQP-21 to C3AR1 not only has effects on signaling but also modulates cellular functions
Title: Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
Role of C3ar1 in the development of the rat cerebellum is reported.
Title: Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum.
results provide the first evidence that C3aR and C5aR are both expressed in cerebellar granule cells during development and that C5a, but not C3a, is a potent inhibitor of apoptotic cell death in cultured granule neurons
Title: Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death.

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General gene information

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Markers

D4Got128 (e-PCR)
- UniSTS:112197

RH138462 (e-PCR)
- UniSTS:220549

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C3a binding	IDA Inferred from Direct Assay more info	PubMed
enables complement component C3a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C3a receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables complement component C3a receptor activity	IEA Inferred from Electronic Annotation more info
enables complement component C3a receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables complement component C3a receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement component C5a signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement receptor mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glomerular mesangial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in tolerance induction to nonself antigen	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C3a anaphylatoxin chemotactic receptor

Names: C3AR; C3a-R; complement component 3a receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032060.2 → NP_114449.2 C3a anaphylatoxin chemotactic receptor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

O55197

UniProtKB/TrEMBL

A6ILG1, G3V759

Related

ENSRNOP00000012216.2, ENSRNOT00000012216.5

Conserved Domains (2) summary

cd14964
Location:25 → 51

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:24 → 434

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

157747419..157756609 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237314.5 → XP_006237376.1 C3a anaphylatoxin chemotactic receptor isoform X1

See identical proteins and their annotated locations for XP_006237376.1

UniProtKB/Swiss-Prot

O55197

UniProtKB/TrEMBL

A6ILG1, G3V759

Related

ENSRNOP00000094051.1, ENSRNOT00000106930.2

Conserved Domains (2) summary

cd14964
Location:25 → 51

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:24 → 434

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily