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    Mecp2 methyl CpG binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29386, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mecp2provided by RGD
    Official Full Name
    methyl CpG binding protein 2provided by RGD
    Primary source
    RGD:3075
    See related
    EnsemblRapid:ENSRNOG00000056659 AllianceGenome:RGD:3075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MECP2_e1
    Summary
    Enables several functions, including DNA binding activity; histone deacetylase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including central nervous system development; positive regulation of dense core granule transport; and regulation of dendrite extension. Located in chromatin. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study Rett syndrome. Biomarker of fetal alcohol spectrum disorder; hepatocellular carcinoma; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 91.9), Lung (RPKM 87.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mecp2 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156932481..156995981, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151781177..151844687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156650389..156713813)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA61 Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132 Neighboring gene lipoic acid synthetase, pseudogene 1 Neighboring gene protein Mis18-beta-like Neighboring gene opsin 1, medium wave sensitive

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin DNA binding PubMed 
    enables chromatin binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables double-stranded methylated DNA binding  
    enables double-stranded methylated DNA binding PubMed 
    enables double-stranded methylated DNA binding  
    enables double-stranded methylated DNA binding  
    enables enzyme binding PubMed 
    enables four-way junction DNA binding PubMed 
    enables histone deacetylase binding PubMed 
    enables histone reader activity  
    enables identical protein binding PubMed 
    enables mRNA binding  
    enables methyl-CpG binding  
    enables methyl-CpG binding PubMed 
    enables methyl-CpG binding  
    enables molecular adaptor activity  
    enables molecular condensate scaffold activity  
    enables nucleic acid binding  
    enables promoter-specific chromatin binding PubMed 
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables siRNA binding  
    enables transcription corepressor activity  
    enables unmethylated CpG binding PubMed 
    Items 1 - 25 of 28
    Items 1 - 25 of 112
    Process Evidence Code Pubs
    involved_in Notch signaling pathway  
    acts_upstream_of_or_within adult locomotory behavior  
    involved_in associative learning  
    acts_upstream_of_or_within behavioral fear response  
    acts_upstream_of_or_within biogenic amine metabolic process  
    acts_upstream_of_or_within brain development  
    acts_upstream_of_or_within cardiolipin metabolic process  
    acts_upstream_of catecholamine secretion  
    acts_upstream_of cell population proliferation  
    involved_in cellular response to isoquinoline alkaloid PubMed 
    involved_in cellular response to potassium ion PubMed 
    involved_in cerebellum development PubMed 
    acts_upstream_of_or_within cerebellum development  
    involved_in cerebral cortex development PubMed 
    acts_upstream_of_or_within chemical synaptic transmission  
    acts_upstream_of_or_within dendrite development  
    involved_in epigenetic regulation of gene expression PubMed 
    involved_in epigenetic regulation of gene expression PubMed 
    acts_upstream_of_or_within epigenetic regulation of gene expression  
    acts_upstream_of_or_within excitatory postsynaptic potential  
    involved_in gene expression  
    acts_upstream_of_or_within genomic imprinting  
    acts_upstream_of glial cell proliferation  
    acts_upstream_of_or_within glucocorticoid metabolic process  
    acts_upstream_of_or_within glutamine metabolic process  
    acts_upstream_of_or_within heterochromatin formation  
    involved_in hippocampus development PubMed 
    acts_upstream_of_or_within inositol metabolic process  
    acts_upstream_of_or_within learning  
    acts_upstream_of_or_within long-term memory  
    acts_upstream_of_or_within long-term synaptic potentiation  
    involved_in lung alveolus development PubMed 
    acts_upstream_of_or_within memory  
    acts_upstream_of_or_within multicellular organismal response to stress  
    involved_in negative regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of astrocyte differentiation PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of dendrite extension PubMed 
    involved_in negative regulation of dendritic spine development PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation  
    involved_in negative regulation of locomotion involved in locomotory behavior PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process  
    involved_in negative regulation of primary miRNA processing PubMed 
    involved_in negative regulation of respiratory gaseous exchange PubMed 
    involved_in negative regulation of smooth muscle cell differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure  
    acts_upstream_of_or_within neuromuscular process  
    acts_upstream_of_or_within neuromuscular process controlling posture  
    involved_in neuron differentiation PubMed 
    acts_upstream_of_or_within neuron differentiation  
    involved_in neuron differentiation  
    acts_upstream_of_or_within neuron maturation  
    acts_upstream_of_or_within neuron projection development  
    involved_in olfactory bulb development PubMed 
    involved_in oligodendrocyte development PubMed 
    involved_in oligodendrocyte differentiation PubMed 
    acts_upstream_of_or_within phosphatidylcholine metabolic process  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of anterograde dense core granule transport PubMed 
    involved_in positive regulation of branching morphogenesis of a nerve PubMed 
    involved_in positive regulation of dendrite extension PubMed 
    involved_in positive regulation of dendritic spine development PubMed 
    involved_in positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of glial cell proliferation  
    involved_in positive regulation of microtubule nucleation  
    involved_in positive regulation of retrograde dense core granule transport PubMed 
    involved_in positive regulation of synaptic plasticity PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within post-embryonic development  
    involved_in principal sensory nucleus of trigeminal nerve development PubMed 
    acts_upstream_of_or_within proprioception  
    acts_upstream_of_or_within protein localization  
    involved_in regulation of action potential firing threshold PubMed 
    acts_upstream_of_or_within regulation of gene expression  
    acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process  
    involved_in regulation of synapse organization PubMed 
    involved_in regulation of synapse organization PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system  
    involved_in response to alcohol PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to estradiol PubMed 
    acts_upstream_of_or_within response to hypoxia  
    involved_in response to ionizing radiation PubMed 
    involved_in response to lead ion PubMed 
    involved_in response to organic cyclic compound PubMed 
    acts_upstream_of_or_within response to other organism  
    acts_upstream_of_or_within sensory perception of pain  
    involved_in social behavior PubMed 
    acts_upstream_of_or_within social behavior  
    involved_in spinal cord development PubMed 
    acts_upstream_of_or_within startle response  
    involved_in striatum development PubMed 
    acts_upstream_of_or_within synapse assembly  
    involved_in thalamus development PubMed 
    acts_upstream_of trans-synaptic signaling by BDNF  
    involved_in ventricular cardiac muscle tissue development PubMed 
    acts_upstream_of_or_within ventricular system development  
    acts_upstream_of_or_within visual learning  
    Items 1 - 25 of 112
    Component Evidence Code Pubs
    located_in centrosome  
    located_in chromatin PubMed 
    located_in cytoplasm  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in heterochromatin  
    located_in heterochromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in postsynapse  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    methyl-CpG-binding protein 2
    Names
    meCP-2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431554.1NP_001418483.1  methyl-CpG-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6ABA1, A6KRS9
    2. NM_022673.3NP_073164.2  methyl-CpG-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_073164.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q00566, Q09HV7, Q09HV8
      UniProtKB/TrEMBL
      A0A0G2JWK2, A6KRS9
      Conserved Domains (1) summary
      smart00391
      Location:92169
      MBD; Methyl-CpG binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156932481..156995981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099534.2XP_038955462.1  methyl-CpG-binding protein 2 isoform X1

      Conserved Domains (1) summary
      smart00391
      Location:120197
      MBD; Methyl-CpG binding domain
    2. XM_063279838.1XP_063135908.1  methyl-CpG-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q00566, Q09HV7, Q09HV8
      UniProtKB/TrEMBL
      A0A0G2JWK2, A6KRS9
    3. XM_017601935.3XP_017457424.1  methyl-CpG-binding protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q00566, Q09HV7, Q09HV8
      UniProtKB/TrEMBL
      A0A8I6ABA1, A6KRS9
      Related
      ENSRNOP00000069913.2, ENSRNOT00000085723.3
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