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    B3gat2 beta-1,3-glucuronyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3gat2provided by RGD
    Official Full Name
    beta-1,3-glucuronyltransferase 2provided by RGD
    Primary source
    RGD:620903
    See related
    EnsemblRapid:ENSRNOG00000046852 AllianceGenome:RGD:620903
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Involved in carbohydrate biosynthetic process. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 42.6), Thymus (RPKM 6.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3gat2 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (33663482..33746466)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (26167174..26250153)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (29984077..30068649)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene opioid growth factor receptor-like 1 Neighboring gene uncharacterized LOC120094843 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene 60S ribosomal protein L29-like Neighboring gene small ArfGAP 1 Neighboring gene succinate dehydrogenase complex assembly factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of a second glucuronyltransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope. Seiki T, et al. Biochem Biophys Res Commun, 1999 Feb 5. PMID 10082676
    2. Cloning and expression of a novel galactoside beta1, 3-glucuronyltransferase involved in the biosynthesis of HNK-1 epitope. Shimoda Y, et al. J Biol Chem, 1999 Jun 11. PMID 10358066
    3. Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism. Rühle F, et al. Blood, 2017 Feb 9. PMID 28011674
    4. Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus. Yu M, et al. Cancer Epidemiol Biomarkers Prev, 2015 Dec. PMID 26545406, Free PMC Article
    5. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. Kähler AK, et al. Biol Psychiatry, 2011 Jan 1. PMID 20950796

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
    Names
    UDP-glucuronosyltransferase S
    galactoside beta-1,3-glucuronyltransferase
    glcAT-D
    glcAT-S
    glucuronosyltransferase S
    NP_072131.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022609.2 → NP_072131.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_072131.1

      Status: PROVISIONAL

      Source sequence(s)
      AB010441
      UniProtKB/Swiss-Prot
      Q9Z137
      UniProtKB/TrEMBL
      A6JJA7, M0R3R1
      Related
      ENSRNOP00000063982.2, ENSRNOT00000075592.3
      Conserved Domains (1) summary
      cd00218
      Location:81 → 306
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      33663482..33746466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z137.1 GenPept UniProtKB/Swiss-Prot:Q9Z137

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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