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    Atp2c1 ATPase secretory pathway Ca2+ transporting 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170699, updated on 9-Dec-2024

    Summary

    Symbol
    Atp2c1provided by RGD
    Full Name
    ATPase secretory pathway Ca2+ transporting 1provided by RGD
    Primary source
    RGD:621311
    See related
    EnsemblRapid:ENSRNOG00000013305 AllianceGenome:RGD:621311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spca1
    Summary
    Enables P-type calcium transporter activity. Involved in calcium ion transport and intracellular calcium ion homeostasis. Located in secretory granule. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Orthologous to human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 384.0), Kidney (RPKM 263.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp2c1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (114913551..115034706, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106034777..106155854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (113953959..114039965, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene microRNA 6330 Neighboring gene NIMA-related kinase 11 Neighboring gene spermine synthase, pseudogene 1 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2, pseudogene 1 Neighboring gene asteroid homolog 1 Neighboring gene 5S ribosomal RNA Neighboring gene ribosomal protein L29, pseudogene 14 Neighboring gene ribosomal protein L29

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC93231

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables P-type calcium transporter activity PubMed 
    enables P-type calcium transporter activity  
    NOT enables P-type calcium transporter activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity  
    enables P-type ion transporter activity  
    enables P-type manganese transporter activity  
    enables P-type manganese transporter activity  
    enables P-type manganese transporter activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables manganese ion binding  
    enables manganese ion binding  
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in Golgi calcium ion homeostasis  
    involved_in Golgi calcium ion homeostasis  
    involved_in Golgi calcium ion homeostasis  
    involved_in Golgi calcium ion transport PubMed 
    involved_in Golgi calcium ion transport  
    involved_in Golgi calcium ion transport  
    involved_in Golgi calcium ion transport  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in calcium ion import PubMed 
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport PubMed 
    involved_in calcium ion transport PubMed 
    involved_in calcium ion transport  
    involved_in calcium ion transport  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in epidermis development  
    involved_in epidermis development  
    involved_in epidermis development  
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis PubMed 
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular manganese ion homeostasis  
    involved_in intracellular manganese ion homeostasis  
    involved_in manganese ion transmembrane transport  
    involved_in manganese ion transport  
    involved_in manganese ion transport  
    involved_in manganese ion transport  
    involved_in positive regulation of Golgi to plasma membrane protein transport  
    involved_in positive regulation of Golgi to plasma membrane protein transport  
    involved_in positive regulation of Golgi to plasma membrane protein transport  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in trans-Golgi network membrane organization  
    involved_in trans-Golgi network membrane organization  
    involved_in trans-Golgi network membrane organization  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi cisterna membrane  
    located_in Golgi cisterna membrane  
    located_in Golgi cisterna membrane  
    is_active_in Golgi membrane  
    located_in Golgi membrane  
    located_in Golgi membrane  
    located_in Golgi membrane  
    located_in cis-Golgi network membrane  
    located_in cis-Golgi network membrane  
    located_in endomembrane system  
    is_active_in endoplasmic reticulum  
    located_in membrane  
    is_active_in plasma membrane  
    located_in secretory granule PubMed 
    located_in trans-Golgi network  
    located_in trans-Golgi network  
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    calcium-transporting ATPase type 2C member 1
    Names
    ATP-dependent Ca(2+) pump PMR1
    ATPase 2C1
    ATPase, Ca++ transporting, type 2C, member 1
    ATPase, Ca++-sequestering
    Ca(2+)/Mn(2+)-ATPase 2C1
    calcium-transporting ATPase 2C1
    secretory pathway Ca(2+)-ATPase 1
    secretory pathway Ca(2+)-transporting ATPase type 1
    NP_571982.2
    XP_038936657.1
    XP_063120874.1
    XP_063120875.1
    XP_063120876.1
    XP_063120877.1
    XP_063120878.1
    XP_063120879.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131907.2NP_571982.2  calcium-transporting ATPase type 2C member 1

      See identical proteins and their annotated locations for NP_571982.2

      Status: PROVISIONAL

      Source sequence(s)
      BC086994
      UniProtKB/Swiss-Prot
      Q64566, Q64567
      UniProtKB/TrEMBL
      A0A8I6GM06, A6I2N4, Q5PQW5
      Related
      ENSRNOP00000096296.1, ENSRNOT00000095638.2
      Conserved Domains (6) summary
      TIGR01522
      Location:23903
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:611679
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:106339
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:726898
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:2694
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:410493
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      114913551..115034706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080729.2XP_038936657.1  calcium-transporting ATPase type 2C member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G9F5, A6I2N3
      Related
      ENSRNOP00000085864.1, ENSRNOT00000103991.2
      Conserved Domains (1) summary
      cd02085
      Location:88930
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    2. XM_063264808.1XP_063120878.1  calcium-transporting ATPase type 2C member 1 isoform X3

      UniProtKB/Swiss-Prot
      Q64566, Q64567
    3. XM_063264805.1XP_063120875.1  calcium-transporting ATPase type 2C member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y5G2
    4. XM_063264807.1XP_063120877.1  calcium-transporting ATPase type 2C member 1 isoform X3

      UniProtKB/Swiss-Prot
      Q64566, Q64567
    5. XM_063264809.1XP_063120879.1  calcium-transporting ATPase type 2C member 1 isoform X4

      UniProtKB/Swiss-Prot
      Q64566, Q64567
      UniProtKB/TrEMBL
      A0A8I6A6R2
    6. XM_063264806.1XP_063120876.1  calcium-transporting ATPase type 2C member 1 isoform X3

      UniProtKB/Swiss-Prot
      Q64566, Q64567
      Related
      ENSRNOP00000088420.1, ENSRNOT00000097914.2
    7. XM_063264804.1XP_063120874.1  calcium-transporting ATPase type 2C member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y5G2

    RNA

    1. XR_005487741.2 RNA Sequence

    2. XR_010053920.1 RNA Sequence

    3. XR_010053923.1 RNA Sequence

    4. XR_010053924.1 RNA Sequence

    5. XR_010053922.1 RNA Sequence

    6. XR_010053921.1 RNA Sequence

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