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    Wwtr1 WW domain containing transcription regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295062, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wwtr1provided by RGD
    Official Full Name
    WW domain containing transcription regulator 1provided by RGD
    Primary source
    RGD:1559609
    See related
    EnsemblRapid:ENSRNOG00000016617 AllianceGenome:RGD:1559609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; kidney development; and negative regulation of fat cell differentiation. Located in nucleus. Orthologous to human WWTR1 (WW domain containing transcription regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Some orthologs of Taz (Gene ID: 363521) and Wwtr1 (Gene ID: 295062), such as the human and mouse orthologs, share the Taz symbol/alias in common. Taz is a widely used alternative name for WW domain-containing transcription regulator protein 1 (Wwtr1), which can be confused with the official symbol for tafazzin (Taz). [20 Dec 2019]
    Expression
    Biased expression in Heart (RPKM 216.1), Lung (RPKM 209.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Wwtr1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (143801181..143916941, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (141651159..141766919, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147577149..147693033, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene transmembrane 4 L six family member 4 Neighboring gene ribosomal protein L12, pseudogene 2 Neighboring gene uncharacterized LOC108350015 Neighboring gene COMM domain containing 2 Neighboring gene ankyrin repeat and ubiquitin domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC116096

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coregulator activity  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    involved_in SMAD protein signal transduction  
    acts_upstream_of_or_within cilium assembly  
    acts_upstream_of_or_within glomerulus development  
    involved_in heart process  
    involved_in hippo signaling  
    involved_in hippo signaling  
    acts_upstream_of_or_within kidney morphogenesis  
    acts_upstream_of_or_within mesenchymal cell differentiation  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein phosphorylation  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within osteoblast differentiation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within protein ubiquitination  
    involved_in protein ubiquitination  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within regulation of metanephric nephron tubule epithelial cell differentiation  
    involved_in stem cell division  
    involved_in tissue homeostasis  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in bicellular tight junction  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in tight junction  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    WW domain-containing transcription regulator protein 1
    Names
    transcriptional co-activator with PDZ-binding motif (TA)Z
    transcriptional co-activator with PDZ-binding motif (TAZ)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024869.1NP_001020040.1  WW domain-containing transcription regulator protein 1

      See identical proteins and their annotated locations for NP_001020040.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097968
      UniProtKB/TrEMBL
      F7F4A7, Q4V7E6
      Related
      ENSRNOP00000022507.4, ENSRNOT00000022507.7
      Conserved Domains (1) summary
      smart00456
      Location:125156
      WW; Domain with 2 conserved Trp (W) residues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      143801181..143916941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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