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    Chd8 chromodomain helicase DNA binding protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65027, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chd8provided by RGD
    Official Full Name
    chromodomain helicase DNA binding protein 8provided by RGD
    Primary source
    RGD:620696
    See related
    EnsemblRapid:ENSRNOG00000025011 AllianceGenome:RGD:620696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CHD-8
    Summary
    This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene in mice causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations in mice result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in Thymus (RPKM 153.8), Spleen (RPKM 135.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Chd8 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27379285..27438959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24905789..24965461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28612932..28672574, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene RPGR interacting protein 1 Neighboring gene uncharacterized LOC120096964 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene ribosomal protein L9, pseudogene 29 Neighboring gene small nucleolar RNA, C/D box 8 Neighboring gene U6 spliceosomal RNA Neighboring gene RAB2B, member RAS oncogene family Neighboring gene Small nucleolar RNA SNORA72

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 41
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent chromatin remodeler activity  
    enables ATP-dependent chromatin remodeler activity  
    enables ATP-dependent chromatin remodeler activity  
    enables ATP-dependent chromatin remodeler activity  
    enables DNA binding  
    enables DNA binding  
    enables DNA binding  
    enables DNA binding  
    enables DNA clamp loader activity  
    enables DNA helicase activity  
    enables armadillo repeat domain binding PubMed 
    enables beta-catenin binding PubMed 
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables chromatin binding  
    enables chromatin binding  
    enables chromatin binding  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded DNA helicase activity  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables histone binding  
    enables histone binding  
    enables histone binding  
    enables histone binding  
    enables hydrolase activity  
    enables methylated histone binding  
    enables methylated histone binding  
    enables methylated histone binding  
    enables p53 binding  
    enables p53 binding  
    enables p53 binding  
    enables protein binding PubMed 
    enables single-stranded 3'-5' DNA helicase activity  
    Items 1 - 25 of 41
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in Wnt signaling pathway  
    involved_in brain development  
    involved_in brain development  
    acts_upstream_of_or_within brain development  
    involved_in brain development  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in digestive tract development  
    involved_in digestive tract development  
    acts_upstream_of_or_within digestive tract development  
    involved_in digestive tract development  
    involved_in in utero embryonic development  
    acts_upstream_of_or_within in utero embryonic development  
    involved_in mRNA processing  
    involved_in mRNA processing  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of Wnt signaling pathway PubMed 
    involved_in negative regulation of Wnt signaling pathway  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of fibroblast apoptotic process  
    acts_upstream_of_or_within negative regulation of fibroblast apoptotic process  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in prepulse inhibition  
    acts_upstream_of_or_within prepulse inhibition  
    involved_in social behavior  
    acts_upstream_of_or_within social behavior  
    acts_upstream_of_or_within startle response  
    Items 1 - 25 of 51
    Component Evidence Code Pubs
    part_of MLL1 complex  
    part_of MLL1 complex  
    part_of MLL1 complex  
    part_of MLL1 complex  
    located_in chromatin  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  

    General protein information

    Preferred Names
    chromodomain-helicase-DNA-binding protein 8
    Names
    ATP-dependent helicase CHD8
    axis duplication inhibitor
    beta-catenin binding protein
    duplin
    NP_001334590.1
    XP_006251970.1
    XP_006251971.1
    XP_006251972.1
    XP_006251974.1
    XP_038949571.1
    XP_063130687.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347661.1NP_001334590.1  chromodomain-helicase-DNA-binding protein 8

      Status: VALIDATED

      Source sequence(s)
      AF169825, JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX5
      UniProtKB/TrEMBL
      A0A8L2QBK0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27379285..27438959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274617.1XP_063130687.1  chromodomain-helicase-DNA-binding protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9JIX5
      UniProtKB/TrEMBL
      A0A8L2QBK0
    2. XM_006251912.5XP_006251974.1  chromodomain-helicase-DNA-binding protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QBK0
      Related
      ENSRNOP00000022593.7, ENSRNOT00000022593.8
      Conserved Domains (6) summary
      cd00024
      Location:644704
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:830979
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:8141101
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11331247
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:725781
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      cl02688
      Location:23272366
      BRK; BRK domain
    3. XM_006251908.5XP_006251970.1  chromodomain-helicase-DNA-binding protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006251970.1

      UniProtKB/TrEMBL
      A0A8L2QBK0, A0A8L2R557
      Conserved Domains (7) summary
      smart00592
      Location:23182362
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:644704
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:830979
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:8141101
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11331247
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:725781
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      cl02688
      Location:23872426
      BRK; BRK domain
    4. XM_006251910.5XP_006251972.1  chromodomain-helicase-DNA-binding protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006251972.1

      UniProtKB/TrEMBL
      A0A8L2QBK0, A0A8L2R557
      Conserved Domains (7) summary
      smart00592
      Location:23182362
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:644704
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:830979
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:8141101
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11331247
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:725781
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      cl02688
      Location:23872426
      BRK; BRK domain
    5. XM_006251909.5XP_006251971.1  chromodomain-helicase-DNA-binding protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006251971.1

      UniProtKB/TrEMBL
      A0A8L2QBK0, A0A8L2R557
      Related
      ENSRNOP00000071948.2, ENSRNOT00000087722.3
      Conserved Domains (7) summary
      smart00592
      Location:23182362
      BRK; domain in transcription and CHROMO domain helicases
      cd00024
      Location:644704
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:830979
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:8141101
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11331247
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:725781
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      cl02688
      Location:23872426
      BRK; BRK domain
    6. XM_039093643.2XP_038949571.1  chromodomain-helicase-DNA-binding protein 8 isoform X4

      Conserved Domains (7) summary
      PTZ00121
      Location:447583
      PTZ00121; MAEBL; Provisional
      PLN03142
      Location:8101409
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      PHA03247
      Location:68279
      PHA03247; large tegument protein UL36; Provisional
      cd18663
      Location:721779
      CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18668
      Location:638703
      CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
      cd18060
      Location:8111032
      DEXHc_CHD8; DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8
      cl41773
      Location:143442
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

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